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10.1161/JAHA.117.007802 http://scihub22266oqcxt.onion/10.1161/JAHA.117.007802 C6015277!6015277!29678826     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29678826&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2018 ; 7 (9): ä Nephropedia Template TP {{tp|p=29678826|t=2018. RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA |pdf=|usr=}}{{29678826}} gab.com Text RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=29678826 #FOAvip Background: Although transcription is the initial process of gene expression, posttranscriptional gene expression regulation has also played a critical role for fine?tuning gene expression in a fast, precise, and cost?effective manner. Although the regulation of sodium channel ??subunit (SCN5A) mRNA expression has been studied at both transcriptional and pre?mRNA splicing levels, the molecular mechanisms governing SCN5A mRNA expression are far from clear. Methods and Results: Herein, we show that, as evidenced by ribonucleoprotein immunoprecipitation assay, RNA binding protein Hu antigen R/ELAV like RNA binding protein 1 (HuR/ELAVL1) and myocyte enhancer factor?2C (MEF2C) transcription factor mRNA are associated. HuR positively regulated transcription factor MEF2C mRNA expression by protecting its mRNA from degradation. As demonstrated by both chromatin immunoprecipitation?quantitative polymerase chain reaction assay and an electrophoretic mobility shift assay, MEF2C enhanced SCN5A transcription by binding to a putative MEF2C binding site within SCN5A promoter region. Overexpression of HuR increased the expression of SCN5A mRNA, and this effect was attenuated by the presence of MEF2C small interfering RNA in cardiomyocytes. Conclusions: In conclusion, our results suggested that HuR participates in a combined network at the DNA and RNA levels that regulates SCN5A mRNA expression. HuR upregulates MEF2C mRNA expression by protecting MEF2C mRNA from degradation, and consequently, the elevated MEF2C enhances SCN5A mRNA transcription. Twit Text FOAVip RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=29678826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29678826 #FOAvip English Wikipedia <ref>{{Cite pmid|29678826}}</ref> RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA #MMPMID29678826 Zhou A; Shi G; Kang G; Xie A; Liu H; Jiang N; Liu M; Jeong E; Dudley SC J Am Heart Assoc 2018[May]; 7 (9): ä PMID29678826show ga Background: Although transcription is the initial process of gene expression, posttranscriptional gene expression regulation has also played a critical role for fine?tuning gene expression in a fast, precise, and cost?effective manner. Although the regulation of sodium channel ??subunit (SCN5A) mRNA expression has been studied at both transcriptional and pre?mRNA splicing levels, the molecular mechanisms governing SCN5A mRNA expression are far from clear. Methods and Results: Herein, we show that, as evidenced by ribonucleoprotein immunoprecipitation assay, RNA binding protein Hu antigen R/ELAV like RNA binding protein 1 (HuR/ELAVL1) and myocyte enhancer factor?2C (MEF2C) transcription factor mRNA are associated. HuR positively regulated transcription factor MEF2C mRNA expression by protecting its mRNA from degradation. As demonstrated by both chromatin immunoprecipitation?quantitative polymerase chain reaction assay and an electrophoretic mobility shift assay, MEF2C enhanced SCN5A transcription by binding to a putative MEF2C binding site within SCN5A promoter region. Overexpression of HuR increased the expression of SCN5A mRNA, and this effect was attenuated by the presence of MEF2C small interfering RNA in cardiomyocytes. Conclusions: In conclusion, our results suggested that HuR participates in a combined network at the DNA and RNA levels that regulates SCN5A mRNA expression. HuR upregulates MEF2C mRNA expression by protecting MEF2C mRNA from degradation, and consequently, the elevated MEF2C enhances SCN5A mRNA transcription. äRNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizi(epmc).pdf DeepDyve Pubget Overpricing