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10.1038/s41598-018-27918-9 http://scihub22266oqcxt.onion/10.1038/s41598-018-27918-9 C6015081!6015081 !29934555     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29934555 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 9497 Nephropedia Template TP {{tp|p=29934555 |t=2018. HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations |pdf=|usr=}}{{29934555 }} gab.com Text HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29934555 #FOAvip Acute kidney injury (AKI) is a common and potentially lethal complication in the hospitalized patients, with hypoxic injury being as a major cause. The loss of renal tubular epithelial cells (TEC), one of the AKI hallmarks, is potentially followed by tubular regeneration process orchestrated by the remaining uninjured TECs that undergo proliferation and migration. In this study, we used human primary TEC to investigate the initiation of tubular cell migration and associated cytoskeletal alterations in response to pharmacological HIF stabilization which resembles the pathophysiology of hypoxia. Tubular cells have been shown to migrate as cohorts in a wound healing assay. Importantly, cells of distal tubular origin moved faster than those of proximal origin. HIF stabilization impaired TEC migration, which was confirmed by live single cell tracking. HIF stabilization significantly reduced tubular cell migration velocity and promoted cell spreading. In contrast to the control conditions, HIF stabilization induced actin filaments rearrangement and cell adhesion molecules including paxillin and focal adhesion kinase. Condensed bundling of keratin fibers was also observed, while the expression of different types of keratins, phosphorylation of keratin 18, and the microtubule structure were not altered. In summary, HIF stabilization reduced the ability of renal tubular cells to migrate and led to cytoskeleton reorganization. Our data suggested an important involvement of HIF stabilization during the epithelial migration underlying the mechanism of renal regeneration in response to AKI. Twit Text FOAVip HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29934555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29934555 #FOAvip English Wikipedia <ref>{{Cite pmid|29934555 }}</ref> HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations #MMPMID29934555 Müller S ; Djudjaj S ; Lange J ; Iacovescu M ; Goppelt-Struebe M ; Boor P Sci Rep 2018[Jun]; 8 (1 ): 9497 PMID29934555 show ga Acute kidney injury (AKI) is a common and potentially lethal complication in the hospitalized patients, with hypoxic injury being as a major cause. The loss of renal tubular epithelial cells (TEC), one of the AKI hallmarks, is potentially followed by tubular regeneration process orchestrated by the remaining uninjured TECs that undergo proliferation and migration. In this study, we used human primary TEC to investigate the initiation of tubular cell migration and associated cytoskeletal alterations in response to pharmacological HIF stabilization which resembles the pathophysiology of hypoxia. Tubular cells have been shown to migrate as cohorts in a wound healing assay. Importantly, cells of distal tubular origin moved faster than those of proximal origin. HIF stabilization impaired TEC migration, which was confirmed by live single cell tracking. HIF stabilization significantly reduced tubular cell migration velocity and promoted cell spreading. In contrast to the control conditions, HIF stabilization induced actin filaments rearrangement and cell adhesion molecules including paxillin and focal adhesion kinase. Condensed bundling of keratin fibers was also observed, while the expression of different types of keratins, phosphorylation of keratin 18, and the microtubule structure were not altered. In summary, HIF stabilization reduced the ability of renal tubular cells to migrate and led to cytoskeleton reorganization. Our data suggested an important involvement of HIF stabilization during the epithelial migration underlying the mechanism of renal regeneration in response to AKI. |*Cell Movement/drug effects [MESH] |Amino Acids, Dicarboxylic/pharmacology [MESH] |Basic Helix-Loop-Helix Transcription Factors/*metabolism [MESH] |Cell Adhesion/drug effects [MESH] |Cell Line [MESH] |Cytoskeleton/drug effects/*metabolism [MESH] |Epithelial Cells/*cytology/drug effects [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Keratins/metabolism [MESH] |Kidney Tubules, Proximal/cytology/drug effects/metabolism [MESH] |Phosphorylation/drug effects [MESH]HIF stabilization inhibits renal epithelial cell migration and is asso(epmc).pdf DeepDyve Pubget Overpricing