Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30023184
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Immunohistochemical panel for differentiating renal cell carcinoma with clear and
papillary features
#MMPMID30023184
Alshenawy HA
J Microsc Ultrastruct
2015[Apr]; 3
(2
): 68-74
PMID30023184
show ga
OBJECTIVES: Renal cell carcinoma (RCC) in which clear cells with papillary
architecture are present is a difficult diagnostic challenge. Clear cell RCC,
rarely has papillary architecture. Papillary RCC rarely contains clear cells.
However, two recently described types; clear cell papillary and Xp11
translocation RCC characteristically feature both papillary and clear cells.
Accurate diagnosis has both prognostic and therapeutic implications. This study
aims to highlight the helpful features of each of these entities to enable
reproducible classification. METHODS: Sixty RCC cases with clear cells and
papillary architecture were selected and classified according to The
International Society of Urological Pathology (ISUP) Vancouver Classification of
Renal Neoplasia and graded according to The International Society of Urological
Pathology (ISUP) grading system for renal cell carcinoma then stained for CK7,
carbonic anhydrase IX (CA IX), ?-methylacyl-CoA-racemase (AMACR) and TFE-3.
RESULTS: The characteristic immunoprofile of Clear RCC is CK7-, AMACR-, CA IX+
and TFE3-, papillary RCC is CK7+, AMACR+, CAIX- and TFE3-, while for clear cell
papillary RCC it is CK7+, AMACR-, CAIX+ and TFE3- and lastly Xp11 translocation
RCC is CK7-, AMACR+, CAIX- and TFE3+. CONCLUSIONS: Staining for CA IX, CK7, AMACR
and TFE3 comprises a concise panel for distinguishing RCC with papillary and
clear pattern.