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10.1042/BSR20180470 http://scihub22266oqcxt.onion/10.1042/BSR20180470 C6013702!6013702 !29871974     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29871974 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biosci+Rep 2018 ; 38 (3 ): ä Nephropedia Template TP {{tp|p=29871974 |t=2018. Nobiletin alleviates endometriosis via down-regulating NF-?B activity in endometriosis mouse model |pdf=|usr=}}{{29871974 }} gab.com Text Nobiletin alleviates endometriosis via down-regulating NF- B activity in endometriosis mouse model JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29871974 #FOAvip Nobiletin exhibits protective potential on inflammation and inhibits the activation of transcription factors nuclear factor-?B (NF-?B). However, its effects on the progression of endometriosis remain unsettled. The present study aimed to explore the in vivo alleviation of nobiletin on endometriosis and its mechanism of action. The mouse model of endometriosis was established and administered with nobiletin. The ectopic lesion size was measured and the hotplate test was performed to assess the amelioration of nobiletin on endometriosis. The expression of proliferation and angiogenesis relevant genes including proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and E-cadherin was measured by immunostaining and the mRNA expression of proinflammatory mediators including interleukin (IL)-6, IL-1?, tumor necrosis factor (TNF)-?, matrix metalloproteinases (MMP)-1, and MMP-3 was measured by RT-PCR. The change of NF-?B activity in endometriotic cells was evaluated by Western blotting and confirmed by luciferase assay. Administration of nobiletin significantly reduced lesions size and pain in endometriosis mice. Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1?, TNF-?, MMP-1, and MMP-3. Nobiletin also showed remarkably impairment on the activation of NF-?B in promoting endometriotic cells, likely targeting on the activity of I?B kinases (IKKs). The present study provides the first evidence that nobiletin exerts protection on endometriosis via inhibition the activation of NF-?B, specifically on the activity of I?B kinases. Twit Text FOAVip Nobiletin alleviates endometriosis via down-regulating NF- B activity in endometriosis mouse model ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29871974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29871974 #FOAvip English Wikipedia <ref>{{Cite pmid|29871974 }}</ref> Nobiletin alleviates endometriosis via down-regulating NF-?B activity in endometriosis mouse model #MMPMID29871974 Wei X ; Shao X Biosci Rep 2018[Jun]; 38 (3 ): ä PMID29871974 show ga Nobiletin exhibits protective potential on inflammation and inhibits the activation of transcription factors nuclear factor-?B (NF-?B). However, its effects on the progression of endometriosis remain unsettled. The present study aimed to explore the in vivo alleviation of nobiletin on endometriosis and its mechanism of action. The mouse model of endometriosis was established and administered with nobiletin. The ectopic lesion size was measured and the hotplate test was performed to assess the amelioration of nobiletin on endometriosis. The expression of proliferation and angiogenesis relevant genes including proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and E-cadherin was measured by immunostaining and the mRNA expression of proinflammatory mediators including interleukin (IL)-6, IL-1?, tumor necrosis factor (TNF)-?, matrix metalloproteinases (MMP)-1, and MMP-3 was measured by RT-PCR. The change of NF-?B activity in endometriotic cells was evaluated by Western blotting and confirmed by luciferase assay. Administration of nobiletin significantly reduced lesions size and pain in endometriosis mice. Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1?, TNF-?, MMP-1, and MMP-3. Nobiletin also showed remarkably impairment on the activation of NF-?B in promoting endometriotic cells, likely targeting on the activity of I?B kinases (IKKs). The present study provides the first evidence that nobiletin exerts protection on endometriosis via inhibition the activation of NF-?B, specifically on the activity of I?B kinases. |Animals [MESH] |Anti-Inflammatory Agents/*pharmacology [MESH] |Cadherins/genetics/metabolism [MESH] |Choristoma/*drug therapy/genetics/pathology/surgery [MESH] |Disease Models, Animal [MESH] |Ectopic Gene Expression [MESH] |Endometriosis/*drug therapy/genetics/metabolism/pathology [MESH] |Endometrium/drug effects/metabolism/pathology/surgery [MESH] |Female [MESH] |Flavones/*pharmacology [MESH] |Humans [MESH] |Injections, Intraperitoneal [MESH] |Interleukin-1beta/genetics/metabolism [MESH] |Interleukin-6/genetics/metabolism [MESH] |Matrix Metalloproteinase 13/genetics/metabolism [MESH] |Matrix Metalloproteinase 3/genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/antagonists & inhibitors/*genetics/metabolism [MESH] |Nociception/*drug effects [MESH] |Proliferating Cell Nuclear Antigen/genetics/metabolism [MESH] |Signal Transduction [MESH] |Tissue Culture Techniques [MESH] |Tumor Necrosis Factor-alpha/genetics/metabolism [MESH]Nobiletin alleviates endometriosis via down-regulating NF-?B activity (epmc).pdf DeepDyve Pubget Overpricing