Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29962913
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29962913
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Med+Libr+Assoc
2018 ; 106
(3
): 352-360
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A comparison of the content and primary literature support for online medication
information provided by Lexicomp and Wikipedia
#MMPMID29962913
Hunter JA
; Lee T
; Persaud N
J Med Libr Assoc
2018[Jul]; 106
(3
): 352-360
PMID29962913
show ga
OBJECTIVES: The research compared the comprehensiveness and accuracy of two
online resources that provide drug information: Lexicomp and Wikipedia. METHODS:
Medication information on five commonly prescribed medications was identified and
comparisons were made between resources and the relevant literature. An initial
content comparison of the following three categories of medication information
was performed: dose and instructions, uses, and adverse effects or warnings. The
content comparison included sixteen points of comparison for each of the five
investigated medications, totaling eighty content comparisons. For each of the
medications, adverse reactions that appeared in only one of the resources were
identified. When primary, peer-reviewed literature was not referenced supporting
the discrepant adverse reactions, a literature search was performed to determine
whether or not evidence existed to support the listed claims. RESULTS: Lexicomp
consistently provided more medication information, with information provided in
95.0% (76/80) of the content, compared to Wikipedia's 42.5% (34/80). Lexicomp and
Wikipedia had information present in 91.4% (32/35) and 20.0% (7/35) of dosing and
instructions content, respectively. Adverse effects or warning content was
provided in 97.5% (39/40) of Lexicomp content and 55.0% (22/40) of Wikipedia
content. The "uses" category was present in both Lexicomp and Wikipedia for the 5
medications considered. Of adverse reactions listed solely in Lexicomp, 191/302
(63.2%) were supported by primary, peer-reviewed literature in contrast to 7/7
(100.0%) of adverse reactions listed only in Wikipedia. A review of US Food and
Drug Administration Prescribing Information and the Adverse Event Reporting
System dashboard found support for a respective 17/102 (16.7%) and 92/102 (90.2%)
of Lexicomp's adverse reactions that were not supported in the literature.
CONCLUSION: Lexicomp is a comprehensive medication information tool that contains
lists of adverse reactions that are not entirely supported by primary-peer
reviewed literature.