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10.1097/CJI.0000000000000229 http://scihub22266oqcxt.onion/10.1097/CJI.0000000000000229 C6012057!6012057 !29864078     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29864078 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth |pdf=|usr=}}{{29864078 }} gab.com Text Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth JO: J Immunother http://www.kidney.de/pget.php?&tw=1&pmid=29864078 #FOAvip Memory stem T (TSCM) cells, a new subset of memory T cells with self-renewal and multipotent capacities, are considered as a promising candidates for adoptive cellular therapy. However, the low proportion of human TSCM cells in total CD8 T cells limits their utility. Here, we aimed to induce human CD8 TSCM cells by stimulating naive precursors with interleukin-21 (IL-21). We found that IL-21 promoted the generation of TSCM cells, described as CD45RACD45ROCD62LCCR7CD122CD95 cells, with a higher efficiency than that observed with other common ?-chain cytokines. Upon adoptive transfer into an A375 melanoma mouse model, these lymphocytes mediated much stronger antitumor responses. Further mechanistic analysis revealed that IL-21 activated the Janus kinase signal transducer and activator of transcription 3 pathway by upregulating signal transducer and activator of transcription 3 phosphorylation and consequently promoting the expression of T-bet and suppressor of cytokine signaling 1, but decreasing the expression of eomesodermin and GATA binding protein 3. Our findings provide novel insights into the generation of human CD8 TSCM cells and reveal a novel potential clinical application of IL-21. Twit Text FOAVip Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth ????J Immunother http://www.kidney.de/pget.php?&tw=1&pmid=29864078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29864078 #FOAvip English Wikipedia <ref>{{Cite pmid|29864078 }}</ref> Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth #MMPMID29864078 Chen Y ; Yu F ; Jiang Y ; Chen J ; Wu K ; Chen X ; Lin Y ; Zhang H ; Li L ; Zhang Y J Immunother 2018[Jul]; 41 (6 ): 274-283 PMID29864078 show ga Memory stem T (TSCM) cells, a new subset of memory T cells with self-renewal and multipotent capacities, are considered as a promising candidates for adoptive cellular therapy. However, the low proportion of human TSCM cells in total CD8 T cells limits their utility. Here, we aimed to induce human CD8 TSCM cells by stimulating naive precursors with interleukin-21 (IL-21). We found that IL-21 promoted the generation of TSCM cells, described as CD45RACD45ROCD62LCCR7CD122CD95 cells, with a higher efficiency than that observed with other common ?-chain cytokines. Upon adoptive transfer into an A375 melanoma mouse model, these lymphocytes mediated much stronger antitumor responses. Further mechanistic analysis revealed that IL-21 activated the Janus kinase signal transducer and activator of transcription 3 pathway by upregulating signal transducer and activator of transcription 3 phosphorylation and consequently promoting the expression of T-bet and suppressor of cytokine signaling 1, but decreasing the expression of eomesodermin and GATA binding protein 3. Our findings provide novel insights into the generation of human CD8 TSCM cells and reveal a novel potential clinical application of IL-21. |Animals [MESH] |CD8-Positive T-Lymphocytes/*immunology/transplantation [MESH] |Cell Growth Processes [MESH] |Cell Line [MESH] |Cell Self Renewal [MESH] |Disease Models, Animal [MESH] |Enzyme-Linked Immunospot Assay [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Immunotherapy, Adoptive/*methods [MESH] |Interleukin-21 [MESH] |Interleukins/*metabolism [MESH] |Janus Kinases/metabolism [MESH] |Melanoma/immunology/*therapy [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Multipotent Stem Cells/*physiology [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction [MESH] |Suppressor of Cytokine Signaling 1 Protein/metabolism [MESH] |T-Box Domain Proteins/genetics/metabolism [MESH] |T-bet Transcription Factor [MESH]Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Ste(epmc).pdf DeepDyve Pubget Overpricing