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10.1186/s13104-018-3510-7

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suck abstract from ncbi


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pmid29925417
      BMC+Res+Notes 2018 ; 11 (1 ): 399
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  • The efficacy of high-dose penicillin G for pneumococcal pneumonia diagnosed based on initial comprehensive assessment at admission: an observational study #MMPMID29925417
  • Komagamine J
  • BMC Res Notes 2018[Jun]; 11 (1 ): 399 PMID29925417 show ga
  • OBJECTIVES: High-dose penicillin therapy is effective in approximately 90% of pneumococcal pneumonia cases diagnosed based on urinary pneumococcal antigen tests or Gram staining at admission. The efficacy of high-dose penicillin therapy for pneumococcal pneumonia diagnosed based on an initial comprehensive assessment comprising a syndromic approach, Gram staining of sputum and urinary pneumococcal antigen testing was investigated. RESULTS: Seventy adult patients diagnosed with pneumococcal pneumonia based on an initial comprehensive assessment and treated with high-dose penicillin G at admission were included. The median patient age was 76.5 years, and 37.1% of the patients were women. The urinary pneumococcal antigen test was positive in 67.1% of all patients, and Gram staining of sputum showed that gram-positive cocci were dominant in 58.6% of the patients. The primary outcome was treatment success based on vital signs until day 6. Treatment with high-dose penicillin G was effective in 87.1% of the patients (95% CI 79.1-95.2%), and the proportion of patients who received other antibiotics because of treatment failure with penicillin G was only 5.7%. The efficacy of high-dose penicillin G treatment for pneumococcal pneumonia diagnosed based on a comprehensive assessment at admission may be comparable to that in previous reports.
  • |*Outcome Assessment, Health Care [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Anti-Bacterial Agents/administration & dosage/*pharmacology [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Patient Admission [MESH]
  • |Penicillin G/administration & dosage/*pharmacology [MESH]
  • |Pneumonia, Pneumococcal/diagnosis/*drug therapy/microbiology/urine [MESH]


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