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10.1155/2018/8212641 http://scihub22266oqcxt.onion/10.1155/2018/8212641 C6011079!6011079 !29977933     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29977933 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol+Res 2018 ; 2018 (ä): 8212641 Nephropedia Template TP {{tp|p=29977933 |t=2018. Expression of G?q Is Decreased in Lymphocytes from Primary Sjögren s Syndrome Patients and Related to Increased IL-17A Expression |pdf=|usr=}}{{29977933 }} gab.com Text Expression of G q Is Decreased in Lymphocytes from Primary Sjögren s Syndrome Patients and Related to Increased IL-17A Expression JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=29977933 #FOAvip Primary Sjögren's syndrome (pSS) is a rheumatic disease characterized by the destruction of salivary and lacrimal glands, and its pathogenesis mechanism remains unclear. G?q is the ?-subunit of the heterotrimeric Gq protein. Researches demonstrated that G?q was involved in the pathogenesis regulation of several rheumatic diseases. This study explored the role of G?q in pSS. G?q mRNA levels in peripheral blood mononuclear cells (PBMCs) from 39 patients and 26 healthy controls (HCs) were investigated using real-time PCR. IL-17A serum concentrations in 22 pSS patients and 23 HCs were tested by ELISA, and the clinical significance of G?q was analyzed. The association of G?q with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. We showed that G?q expression in PBMCs from patients with pSS was significantly lower than that in PBMCs from HCs. G?q expression level was closely associated with pSS disease activity. Furthermore, a negative association was also found in IL-17A and G?q expression level. These data suggest that G?q is involved in pSS pathogenesis regulation, possibly due to its regulation of Th17. These results provide new insights into the pSS pathogenesis mechanism involving abnormal Th17 regulation. Twit Text FOAVip Expression of G q Is Decreased in Lymphocytes from Primary Sjögren s Syndrome Patients and Related to Increased IL-17A Expression ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=29977933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29977933 #FOAvip English Wikipedia <ref>{{Cite pmid|29977933 }}</ref> Expression of G?q Is Decreased in Lymphocytes from Primary Sjögren s Syndrome Patients and Related to Increased IL-17A Expression #MMPMID29977933 Sun Y ; Wang Y ; Chen S ; Fan G ; Zhang J ; Dai F ; Qian H ; Liu Y ; Shi G J Immunol Res 2018[]; 2018 (ä): 8212641 PMID29977933 show ga Primary Sjögren's syndrome (pSS) is a rheumatic disease characterized by the destruction of salivary and lacrimal glands, and its pathogenesis mechanism remains unclear. G?q is the ?-subunit of the heterotrimeric Gq protein. Researches demonstrated that G?q was involved in the pathogenesis regulation of several rheumatic diseases. This study explored the role of G?q in pSS. G?q mRNA levels in peripheral blood mononuclear cells (PBMCs) from 39 patients and 26 healthy controls (HCs) were investigated using real-time PCR. IL-17A serum concentrations in 22 pSS patients and 23 HCs were tested by ELISA, and the clinical significance of G?q was analyzed. The association of G?q with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. We showed that G?q expression in PBMCs from patients with pSS was significantly lower than that in PBMCs from HCs. G?q expression level was closely associated with pSS disease activity. Furthermore, a negative association was also found in IL-17A and G?q expression level. These data suggest that G?q is involved in pSS pathogenesis regulation, possibly due to its regulation of Th17. These results provide new insights into the pSS pathogenesis mechanism involving abnormal Th17 regulation. |Adult [MESH] |Biomarkers [MESH] |Case-Control Studies [MESH] |Female [MESH] |GTP-Binding Protein alpha Subunits, Gq-G11/blood/genetics/*metabolism [MESH] |Humans [MESH] |Interleukin-17/blood/*metabolism [MESH] |Leukocytes, Mononuclear/immunology/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |RNA, Messenger/metabolism [MESH] |Sjogren's Syndrome/genetics/*immunology/metabolism [MESH]Expression of G?q Is Decreased in Lymphocytes from Primary Sjögren s S(epmc).pdf DeepDyve Pubget Overpricing