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10.1155/2018/8702372 http://scihub22266oqcxt.onion/10.1155/2018/8702372 C6011064!6011064!29977619     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Nephrol 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=29977619|t=2018. Transforming Growth Factor-? Protects against Inflammation-Related Atherosclerosis in South African CKD Patients |pdf=|usr=}}{{29977619}} gab.com Text Transforming Growth Factor- Protects against Inflammation-Related Atherosclerosis in South African CKD Patients JO: Int J Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29977619 #FOAvip Background: Transforming growth factor-? (TGF-?) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF-? isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-?1 gene and atherosclerosis in South African CKD patients. Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF-?1, TGF-?2, TGF-?3, endotoxin, and inflammatory markers were measured. Functional polymorphisms in the TGF-?1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography. Results: TGF-? isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001). Overall, TGF-? isoforms had inverse relationships with CIMT. TGF-?1 and TGF-?2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF-?1: 31.9 (17.2 ? 42.2) versus 45.9 (35.4 ? 58.1) ng/ml, p=0.016; and TGF-?2: 1.46 (1.30 ? 1.57) versus 1.70 (1.50 ? 1.87) ng/ml, p=0.013]. In multiple logistic regression, age, TGF-?2, and TGF-?3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 ? 1.109, p=0.039; TGF-?2: OR, 0.996; 95% CI: 0.994?0.999, p=0.018; TGF-?3: OR, 0.992; 95% CI: 0.985?0.999, p=0.029). TGF-?1 genotypes did not influence serum levels of TGF-?1 and no association was found between the TGF-?1 gene polymorphisms and atherosclerosis risk. Conclusion: TGF-? isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients. Twit Text FOAVip Transforming Growth Factor- Protects against Inflammation-Related Atherosclerosis in South African CKD Patients ????Int J Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29977619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29977619 #FOAvip English Wikipedia <ref>{{Cite pmid|29977619}}</ref> Transforming Growth Factor-? Protects against Inflammation-Related Atherosclerosis in South African CKD Patients #MMPMID29977619 Hassan MO; Duarte R; Dix-Peek T; Dickens C; Naidoo S; Vachiat A; Grinter S; Manga P; Naicker S Int J Nephrol 2018[]; 2018 (ä): ä PMID29977619show ga Background: Transforming growth factor-? (TGF-?) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF-? isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-?1 gene and atherosclerosis in South African CKD patients. Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF-?1, TGF-?2, TGF-?3, endotoxin, and inflammatory markers were measured. Functional polymorphisms in the TGF-?1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography. Results: TGF-? isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001). Overall, TGF-? isoforms had inverse relationships with CIMT. TGF-?1 and TGF-?2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF-?1: 31.9 (17.2 ? 42.2) versus 45.9 (35.4 ? 58.1) ng/ml, p=0.016; and TGF-?2: 1.46 (1.30 ? 1.57) versus 1.70 (1.50 ? 1.87) ng/ml, p=0.013]. In multiple logistic regression, age, TGF-?2, and TGF-?3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 ? 1.109, p=0.039; TGF-?2: OR, 0.996; 95% CI: 0.994?0.999, p=0.018; TGF-?3: OR, 0.992; 95% CI: 0.985?0.999, p=0.029). TGF-?1 genotypes did not influence serum levels of TGF-?1 and no association was found between the TGF-?1 gene polymorphisms and atherosclerosis risk. Conclusion: TGF-? isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients. äTransforming Growth Factor-? Protects against Inflammation-Related Ath(epmc).pdf DeepDyve Pubget Overpricing