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10.1111/jcmm.13630 http://scihub22266oqcxt.onion/10.1111/jcmm.13630 C6010858!6010858!29664231     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2018 ; 22 (7): 3308-14 Nephropedia Template TP {{tp|p=29664231|t=2018. Oxidative stress in the pathogenesis of systemic scleroderma: An overview |pdf=|usr=}}{{29664231}} gab.com Text Oxidative stress in the pathogenesis of systemic scleroderma: An overview JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29664231 #FOAvip Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability and death as the result of end?stage organ failure. Two clinical subsets of the SSc are accepted: limited cutaneous SSc (lc?SSc) and diffuse cutaneous SSc (dc?SSc). At present, the aetiology and pathogenesis of SSc remain obscure, and consequently, disease outcome is unpredictable. Numerous studies suggest that reactive oxidizing species (ROS) play an important role in the pathogenesis of scleroderma. Over the years, several reports have supported this hypothesis for both lc?SSc and dc?SSc, although the specific role of oxidative stress in the pathogenesis of vascular injury and fibrosis remains to be clarified. The aim of the present review was to report and comment the recent findings regarding the involvement and role of oxidative stress in SSc pathogenesis. Biomarkers proving the link between ROS and the main pathological features of SSc have been summarized. Twit Text FOAVip Oxidative stress in the pathogenesis of systemic scleroderma: An overview ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29664231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29664231 #FOAvip English Wikipedia <ref>{{Cite pmid|29664231}}</ref> Oxidative stress in the pathogenesis of systemic scleroderma: An overview #MMPMID29664231 Vona R; Giovannetti A; Gambardella L; Malorni W; Pietraforte D; Straface E J Cell Mol Med 2018[Jul]; 22 (7): 3308-14 PMID29664231show ga Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability and death as the result of end?stage organ failure. Two clinical subsets of the SSc are accepted: limited cutaneous SSc (lc?SSc) and diffuse cutaneous SSc (dc?SSc). At present, the aetiology and pathogenesis of SSc remain obscure, and consequently, disease outcome is unpredictable. Numerous studies suggest that reactive oxidizing species (ROS) play an important role in the pathogenesis of scleroderma. Over the years, several reports have supported this hypothesis for both lc?SSc and dc?SSc, although the specific role of oxidative stress in the pathogenesis of vascular injury and fibrosis remains to be clarified. The aim of the present review was to report and comment the recent findings regarding the involvement and role of oxidative stress in SSc pathogenesis. Biomarkers proving the link between ROS and the main pathological features of SSc have been summarized. äOxidative stress in the pathogenesis of systemic scleroderma: An overv(epmc).pdf DeepDyve Pubget Overpricing