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10.1111/jcmm.13608 http://scihub22266oqcxt.onion/10.1111/jcmm.13608 C6010693!6010693!29570934     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2018 ; 22 (7): 3330-9 Nephropedia Template TP {{tp|p=29570934|t=2018. Non?erythropoietic erythropoietin?derived peptide protects mice from systemic lupus erythematosus |pdf=|usr=}}{{29570934}} gab.com Text Non erythropoietic erythropoietin derived peptide protects mice from systemic lupus erythematosus JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29570934 #FOAvip Systemic lupus erythematosus (SLE) is an autoimmune disease, which results in various organ pathologies. However, current treatment towards SLE is suboptimal. Erythropoietin (EPO) has been shown to promote SLE recovery, but clinical application can be limited by its haematopoiesis?stimulating effects. EPO?derived helix?B peptide (ARA290) is non?erythrogenic but has been reported to retain the anti?inflammatory and tissue?protective functions of EPO. Therefore, here we investigated the effects and potential mechanisms of ARA290 on SLE. The administration of ARA290 to pristane?induced SLE and MRL/lpr mice significantly suppressed the level of serum antinuclear autoantibodies (ANAs) and anti?dsDNA autoantibodies, reduced the deposition of IgG and C3, and ameliorated the nephritis symptoms. Moreover, the serum concentrations of inflammatory cytokine IL?6, MCP?1 and TNF?? in SLE mice were reduced by ARA290. Further, ARA290 decreased the number of apoptotic cells in kidney. In vitro experiment revealed that ARA290 inhibited the inflammatory activation of macrophages and promoted the phagocytotic function of macrophages to apoptotic cells. Finally, ARA290 did not induce haematopoiesis during treatment. In conclusion, ARA290 ameliorated SLE, which at least could be partly due to its anti?inflammatory and apoptotic cell clearance promoting effects, without stimulating haematopoiesis, suggesting that ARA290 could be a hopeful candidate for SLE treatment. Twit Text FOAVip Non erythropoietic erythropoietin derived peptide protects mice from systemic lupus erythematosus ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29570934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29570934 #FOAvip English Wikipedia <ref>{{Cite pmid|29570934}}</ref> Non?erythropoietic erythropoietin?derived peptide protects mice from systemic lupus erythematosus #MMPMID29570934 Huang B; Jiang J; Luo B; Zhu W; Liu Y; Wang Z; Zhang Z J Cell Mol Med 2018[Jul]; 22 (7): 3330-9 PMID29570934show ga Systemic lupus erythematosus (SLE) is an autoimmune disease, which results in various organ pathologies. However, current treatment towards SLE is suboptimal. Erythropoietin (EPO) has been shown to promote SLE recovery, but clinical application can be limited by its haematopoiesis?stimulating effects. EPO?derived helix?B peptide (ARA290) is non?erythrogenic but has been reported to retain the anti?inflammatory and tissue?protective functions of EPO. Therefore, here we investigated the effects and potential mechanisms of ARA290 on SLE. The administration of ARA290 to pristane?induced SLE and MRL/lpr mice significantly suppressed the level of serum antinuclear autoantibodies (ANAs) and anti?dsDNA autoantibodies, reduced the deposition of IgG and C3, and ameliorated the nephritis symptoms. Moreover, the serum concentrations of inflammatory cytokine IL?6, MCP?1 and TNF?? in SLE mice were reduced by ARA290. Further, ARA290 decreased the number of apoptotic cells in kidney. In vitro experiment revealed that ARA290 inhibited the inflammatory activation of macrophages and promoted the phagocytotic function of macrophages to apoptotic cells. Finally, ARA290 did not induce haematopoiesis during treatment. In conclusion, ARA290 ameliorated SLE, which at least could be partly due to its anti?inflammatory and apoptotic cell clearance promoting effects, without stimulating haematopoiesis, suggesting that ARA290 could be a hopeful candidate for SLE treatment. äNon?erythropoietic erythropoietin?derived peptide protects mice from s(epmc).pdf DeepDyve Pubget Overpricing