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10.1080/14756366.2018.1455676

http://scihub22266oqcxt.onion/10.1080/14756366.2018.1455676
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C6010108!6010108!29651880
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suck abstract from ncbi

pmid29651880      J+Enzyme+Inhib+Med+Chem 2018 ; 33 (1): 777-93
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  • Small molecule KDM4s inhibitors as anti-cancer agents #MMPMID29651880
  • Lin H; Li Q; Li Q; Zhu J; Gu K; Jiang X; Hu Q; Feng F; Qu W; Chen Y; Sun H
  • J Enzyme Inhib Med Chem 2018[]; 33 (1): 777-93 PMID29651880show ga
  • Histone demethylation is a vital process in epigenetic regulation of gene expression. A number of histone demethylases are present to control the methylated states of histone. Among these enzymes, KDM4s are one subfamily of JmjC KDMs and play important roles in both normal and cancer cells. The discovery of KDM4s inhibitors is a potential therapeutic strategy against different diseases including cancer. Here, we summarize the development of KDM4s inhibitors and some related pharmaceutical information to provide an update of recent progress in KDM4s inhibitors.
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