Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/14756366.2016.1247062 http://scihub22266oqcxt.onion/10.1080/14756366.2016.1247062 C6009933!6009933!28097905     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Enzyme+Inhib+Med+Chem 2017 ; 32 (1): 271-6 Nephropedia Template TP {{tp|p=28097905|t=2017. Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R |pdf=|usr=}}{{28097905}} gab.com Text Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28097905 #FOAvip Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substituted thieno[2,3-d]pyrimidines as epidermal growth factor receptor (EGFR) inhibitors, we characterized the inhibition of EGFR for our novel compounds. As receptor heterodimerization gained certain interest as mechanism of cancer cells to become resistant against novel protein kinase inhibitors, we additionally measured the inhibition of insulin-like growth factor receptor IGF-1R which is a prominent receptor for such heterodimerizations with EGFR. Structure?activity relationships are discussed for both kinase inhibitions depending on the varied substitution patterns. We discovered novel dual inhibitors of both receptor tyrosine kinases with interest for further studies to reduce inhibitor resistance developments in cancer treatment. Twit Text FOAVip Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28097905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28097905 #FOAvip English Wikipedia <ref>{{Cite pmid|28097905}}</ref> Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R #MMPMID28097905 Hempel C; Totzke F; Schächtele C; Najjar A; Sippl W; Ritter C; Hilgeroth A J Enzyme Inhib Med Chem 2017[]; 32 (1): 271-6 PMID28097905show ga Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substituted thieno[2,3-d]pyrimidines as epidermal growth factor receptor (EGFR) inhibitors, we characterized the inhibition of EGFR for our novel compounds. As receptor heterodimerization gained certain interest as mechanism of cancer cells to become resistant against novel protein kinase inhibitors, we additionally measured the inhibition of insulin-like growth factor receptor IGF-1R which is a prominent receptor for such heterodimerizations with EGFR. Structure?activity relationships are discussed for both kinase inhibitions depending on the varied substitution patterns. We discovered novel dual inhibitors of both receptor tyrosine kinases with interest for further studies to reduce inhibitor resistance developments in cancer treatment. äDiscovery of novel dual inhibitors of receptor tyrosine kinases EGFR a(epmc).pdf DeepDyve Pubget Overpricing