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10.1080/14756366.2018.1465416 http://scihub22266oqcxt.onion/10.1080/14756366.2018.1465416 C6009923!6009923!29768059     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29768059.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Enzyme+Inhib+Med+Chem 2018 ; 33 (1): 920-35 Nephropedia Template TP {{tp|p=29768059|t=2018. Pentabromopseudilin: a myosin V inhibitor suppresses TGF-? activity by recruiting the type II TGF-? receptor to lysosomal degradation |pdf=|usr=}}{{29768059}} gab.com Text Pentabromopseudilin: a myosin V inhibitor suppresses TGF- activity by recruiting the type II TGF- receptor to lysosomal degradation JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29768059 #FOAvip Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour, and phytotoxic activities. In mammalian cells, PBrP is known to act as a reversible and allosteric inhibitor of myosin Va (MyoVa). In this study, we report that PBrP is a potent inhibitor of transforming growth factor-? (TGF-?) activity. PBrP inhibits TGF-?-stimulated Smad2/3 phosphorylation, plasminogen activator inhibitor-1 (PAI-1) protein production and blocks TGF-?-induced epithelial?mesenchymal transition in epithelial cells. PBrP inhibits TGF-? signalling by reducing the cell-surface expression of type II TGF-? receptor (T?RII) and promotes receptor degradation. Gene silencing approaches suggest that MyoVa plays a crucial role in PBrP-induced T?RII turnover and the subsequent reduction of TGF-? signalling. Because, TGF-? signalling is crucial in the regulation of diverse pathophysiological processes such as tissue fibrosis and cancer development, PBrP should be further explored for its therapeutic role in treating fibrotic diseases and cancer. Twit Text FOAVip Pentabromopseudilin: a myosin V inhibitor suppresses TGF- activity by recruiting the type II TGF- receptor to lysosomal degradation ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29768059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29768059 #FOAvip English Wikipedia <ref>{{Cite pmid|29768059}}</ref> Pentabromopseudilin: a myosin V inhibitor suppresses TGF-? activity by recruiting the type II TGF-? receptor to lysosomal degradation #MMPMID29768059 Shih-Wei W; Chih-Ling C; Kao YC; Martin R; Knölker HJ; Shiao MS; Chen CL J Enzyme Inhib Med Chem 2018[]; 33 (1): 920-35 PMID29768059show ga Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour, and phytotoxic activities. In mammalian cells, PBrP is known to act as a reversible and allosteric inhibitor of myosin Va (MyoVa). In this study, we report that PBrP is a potent inhibitor of transforming growth factor-? (TGF-?) activity. PBrP inhibits TGF-?-stimulated Smad2/3 phosphorylation, plasminogen activator inhibitor-1 (PAI-1) protein production and blocks TGF-?-induced epithelial?mesenchymal transition in epithelial cells. PBrP inhibits TGF-? signalling by reducing the cell-surface expression of type II TGF-? receptor (T?RII) and promotes receptor degradation. Gene silencing approaches suggest that MyoVa plays a crucial role in PBrP-induced T?RII turnover and the subsequent reduction of TGF-? signalling. Because, TGF-? signalling is crucial in the regulation of diverse pathophysiological processes such as tissue fibrosis and cancer development, PBrP should be further explored for its therapeutic role in treating fibrotic diseases and cancer. äPentabromopseudilin: a myosin V inhibitor suppresses TGF-? activity by(epmc).pdf DeepDyve Pubget Overpricing