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10.1080/14756366.2018.1437729 http://scihub22266oqcxt.onion/10.1080/14756366.2018.1437729 C6009920!6009920 !29482389     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29482389 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido 2,3-d pyrimidine scaffold |pdf=|usr=}}{{29482389 }} gab.com Text Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido 2,3-d pyrimidine scaffold JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29482389 #FOAvip An efficient synthesis of substituted pyrido[2,3-d]pyrimidines was carried out and evaluated for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2), prostate cancer (PC-3), colon cancer (HCT-116), breast cancer (MCF-7), and lung cancer (A-549) cell lines. Regarding HepG-2, PC-3, HCT-116 cancer cell lines, 7-(4-chlorophenyl)-2-(3-methyl-5-oxo-2,3-dihydro-1H-pyrazol-1-yl)-5-(p-tolyl)- pyrido[2,3-d]pyrimidin-4(3H)-one (5a) exhibited strong, more potent anticancer (IC(50): 0.3, 6.6 and 7?然) relative to the standard doxorubicin (IC(50): 0.6, 6.8 and 12.8?然), respectively. Kinase inhibitory assessment of 5a showed promising inhibitory activity against three kinases namely PDGFR ?, EGFR, and CDK4/cyclin D1 at two concentrations 50 and 100?然 in single measurements. Further, a molecular docking study for compound 5a was performed to verify the binding mode towards the EGFR and CDK4/cyclin D1 kinases. Twit Text FOAVip Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido 2,3-d pyrimidine scaffold ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=29482389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29482389 #FOAvip English Wikipedia <ref>{{Cite pmid|29482389 }}</ref> Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido 2,3-d pyrimidine scaffold #MMPMID29482389 Elzahabi HSA ; Nossier ES ; Khalifa NM ; Alasfoury RA ; El-Manawaty MA J Enzyme Inhib Med Chem 2018[Dec]; 33 (1 ): 546-557 PMID29482389 show ga An efficient synthesis of substituted pyrido[2,3-d]pyrimidines was carried out and evaluated for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2), prostate cancer (PC-3), colon cancer (HCT-116), breast cancer (MCF-7), and lung cancer (A-549) cell lines. Regarding HepG-2, PC-3, HCT-116 cancer cell lines, 7-(4-chlorophenyl)-2-(3-methyl-5-oxo-2,3-dihydro-1H-pyrazol-1-yl)-5-(p-tolyl)- pyrido[2,3-d]pyrimidin-4(3H)-one (5a) exhibited strong, more potent anticancer (IC(50): 0.3, 6.6 and 7?然) relative to the standard doxorubicin (IC(50): 0.6, 6.8 and 12.8?然), respectively. Kinase inhibitory assessment of 5a showed promising inhibitory activity against three kinases namely PDGFR ?, EGFR, and CDK4/cyclin D1 at two concentrations 50 and 100?然 in single measurements. Further, a molecular docking study for compound 5a was performed to verify the binding mode towards the EGFR and CDK4/cyclin D1 kinases. |Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Cyclin-Dependent Kinase 4/*antagonists & inhibitors/metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Screening Assays, Antitumor [MESH] |ErbB Receptors/*antagonists & inhibitors/metabolism [MESH] |Humans [MESH] |Models, Molecular [MESH] |Molecular Structure [MESH] |Protein Kinase Inhibitors/chemical synthesis/chemistry/*pharmacology [MESH] |Pyridines/chemical synthesis/chemistry/*pharmacology [MESH] |Pyrimidines/chemical synthesis/chemistry/*pharmacology [MESH] |Receptor, Platelet-Derived Growth Factor beta/*antagonists & inhibitors/metabolism [MESH]Anticancer evaluation and molecular modeling of multi-targeted kinase (epmc).pdf DeepDyve Pubget Overpricing