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10.1080/14756366.2016.1252760 http://scihub22266oqcxt.onion/10.1080/14756366.2016.1252760 C6009900!6009900!28095711     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Enzyme+Inhib+Med+Chem 2017 ; 32 (1): 363-8 Nephropedia Template TP {{tp|p=28095711|t=2017. Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |pdf=|usr=}}{{28095711}} gab.com Text Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28095711 #FOAvip The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC. Twit Text FOAVip Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28095711 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28095711 #FOAvip English Wikipedia <ref>{{Cite pmid|28095711}}</ref> Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice #MMPMID28095711 Astigiano S; Puglisi A; Mastracci L; Fais S; Barbieri O J Enzyme Inhib Med Chem 2017[]; 32 (1): 363-8 PMID28095711show ga The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC. äSystemic alkalinisation delays prostate cancer cell progression in TRA(epmc).pdf DeepDyve Pubget Overpricing