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10.1080/14756366.2016.1252757 http://scihub22266oqcxt.onion/10.1080/14756366.2016.1252757 C6009886!6009886!28097912     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Enzyme+Inhib+Med+Chem 2017 ; 32 (1): 337-44 Nephropedia Template TP {{tp|p=28097912|t=2017. Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain |pdf=|usr=}}{{28097912}} gab.com Text Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28097912 #FOAvip With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent drugs were completely devoid of this ability. In addition, some of them showed a moderate antiproliferative activity on HCT-116 cancer cell line. These results suggest that methanethiosulfonate moiety can be considered a useful scaffold in the preparation of new direct STAT3 inhibitors. Interestingly, an unusual kind of organo-sulfur derivative, endowed with valuable antiproliferative activity, was occasionally isolated. Twit Text FOAVip Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28097912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28097912 #FOAvip English Wikipedia <ref>{{Cite pmid|28097912}}</ref> Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain #MMPMID28097912 Gabriele E; Ricci C; Meneghetti F; Ferri N; Asai A; Sparatore A J Enzyme Inhib Med Chem 2017[]; 32 (1): 337-44 PMID28097912show ga With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent drugs were completely devoid of this ability. In addition, some of them showed a moderate antiproliferative activity on HCT-116 cancer cell line. These results suggest that methanethiosulfonate moiety can be considered a useful scaffold in the preparation of new direct STAT3 inhibitors. Interestingly, an unusual kind of organo-sulfur derivative, endowed with valuable antiproliferative activity, was occasionally isolated. äMethanethiosulfonate derivatives as ligands of the STAT3-SH2 domain (epmc).pdf DeepDyve Pubget Overpricing