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10.1080/14756366.2017.1350658 http://scihub22266oqcxt.onion/10.1080/14756366.2017.1350658 C6009881!6009881 !28738705     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28738705 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Enzyme+Inhib+Med+Chem 2017 ; 32 (1 ): 1012-1028 Nephropedia Template TP {{tp|p=28738705 |t=2017. New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-?B transcription factors |pdf=|usr=}}{{28738705 }} gab.com Text New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF- B transcription factors JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28738705 #FOAvip A set of new sulfurated drug hybrids, mainly derived from caffeic and ferulic acids and rosmaricine, has been synthesized and their ability to inhibit both STAT3 and NF-?B transcription factors have been evaluated. Results showed that most of the new hybrid compounds were able to strongly and selectively bind to STAT3, whereas the parent drugs were devoid of this ability at the tested concentrations. Some of them were also able to inhibit the NF-?B transcriptional activity in HCT-116 cell line and inhibited HCT-116 cell proliferation in vitro with IC(50) in micromolar range, thus suggesting a potential anticancer activity. Taken together, our study described the identification of new derivatives with dual STAT3/NF-?B inhibitory activity, which may represent hit compounds for developing multi-target anticancer agents. Twit Text FOAVip New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF- B transcription factors ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28738705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28738705 #FOAvip English Wikipedia <ref>{{Cite pmid|28738705 }}</ref> New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-?B transcription factors #MMPMID28738705 Gabriele E ; Brambilla D ; Ricci C ; Regazzoni L ; Taguchi K ; Ferri N ; Asai A ; Sparatore A J Enzyme Inhib Med Chem 2017[Dec]; 32 (1 ): 1012-1028 PMID28738705 show ga A set of new sulfurated drug hybrids, mainly derived from caffeic and ferulic acids and rosmaricine, has been synthesized and their ability to inhibit both STAT3 and NF-?B transcription factors have been evaluated. Results showed that most of the new hybrid compounds were able to strongly and selectively bind to STAT3, whereas the parent drugs were devoid of this ability at the tested concentrations. Some of them were also able to inhibit the NF-?B transcriptional activity in HCT-116 cell line and inhibited HCT-116 cell proliferation in vitro with IC(50) in micromolar range, thus suggesting a potential anticancer activity. Taken together, our study described the identification of new derivatives with dual STAT3/NF-?B inhibitory activity, which may represent hit compounds for developing multi-target anticancer agents. |Cell Survival/drug effects [MESH] |Cinnamates/chemical synthesis/chemistry/*pharmacology [MESH] |Diterpenes/chemical synthesis/chemistry/*pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |HCT116 Cells [MESH] |HeLa Cells [MESH] |Humans [MESH] |NF-kappa B/*antagonists & inhibitors/metabolism [MESH] |STAT3 Transcription Factor/*antagonists & inhibitors/metabolism [MESH] |Structure-Activity Relationship [MESH]New sulfurated derivatives of cinnamic acids and rosmaricine as inhibi(epmc).pdf DeepDyve Pubget Overpricing