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10.1080/14756366.2017.1404593

http://scihub22266oqcxt.onion/10.1080/14756366.2017.1404593
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C6009863!6009863!29199484
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pmid29199484      J+Enzyme+Inhib+Med+Chem 2018 ; 33 (1): 147-50
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  • Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A #MMPMID29199484
  • Altamimi AMS; Alafeefy AM; Balode A; Vozny I; Pustenko A; El Shikh ME; Alasmary FAS; Abdel-Gawad SA; ?alubovskis R
  • J Enzyme Inhib Med Chem 2018[]; 33 (1): 147-50 PMID29199484show ga
  • A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC50?=?117?174 µM. Seven compounds exhibited better LDHA inhibition (IC50 117?136 µM) compared to known LDH inhibitor ? galloflavin (IC50 157 µM).
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