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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ScientificWorldJournal 2002 ; 2 (ä): 892-925 Nephropedia Template TP
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The TGF-? Family: Signaling Pathways, Developmental Roles, and Tumor Suppressor Activities #MMPMID12805946
Johnson AN; Newfeld SJ
ScientificWorldJournal 2002[]; 2 (ä): 892-925 PMID12805946show ga
Intercellular communication is a critical process for all multicellular organisms, and communication among cells is required for proper embryonic development and adult physiology. Members of the Transforming Growth Factor-? (TGF-?) family of secreted proteins communicate information between cells via a complex signaling pathway, and family members are capable of inducing a wide range of cellular responses. The purpose of this review is to provide the reader with a broad introduction to our current understanding of three aspects of the TGF-? family. These are the molecular mechanisms utilized by TGF-? signaling pathways, the developmental roles played by TGF-? family members in a variety of species, and the growing list of cancers in which various TGF-? signaling pathways display tumor suppressor activity.