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10.17925/EE.2018.14supp1.2

http://scihub22266oqcxt.onion/10.17925/EE.2018.14supp1.2
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C6009413!6009413!30034546
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suck abstract from ncbi


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pmid30034546      Eur+Endocrinol 2018 ; 14 (Suppl1): 2-9
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  • Second-Generation Insulin Analogues ? a Review of Recent Real-World Data and Forthcoming Head-to-Head Comparisons #MMPMID30034546
  • Mauricio D; Hramiak I
  • Eur Endocrinol 2018[May]; 14 (Suppl1): 2-9 PMID30034546show ga
  • Insulin analogues play a key role in the effective management of type 2 diabetes. However, there are several behavioural barriers to appropriate early initiation of insulin therapy, despite compelling evidence supporting the benefits of this strategy in those patients for whom oral anti-diabetes agents provide insufficient control. The development of second-generation insulin analogues (insulin glargine 300 U/mL and insulin degludec) has provided physicians with agents that can provide comparable glycaemic control to first-generation insulin, but with a reduced risk of hypoglycaemia and modes of action suited to once-daily regimens. These characteristics may help overcome patient and physician concerns about early insulin use in disease management. To date, there have been no head-to-head comparisons of second-generation insulins: here we consider recent real-world evidence and the forthcoming direct comparison in the BRIGHT randomised controlled study, as presented at the recent 11th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) 2018.
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