Second-Generation Insulin Analogues - a Review of Recent Real-World Data and
Forthcoming Head-to-Head Comparisons
#MMPMID30034546
Mauricio D
; Hramiak I
Eur Endocrinol
2018[May]; 14
(Suppl1
): 2-9
PMID30034546
show ga
Insulin analogues play a key role in the effective management of type 2 diabetes.
However, there are several behavioural barriers to appropriate early initiation
of insulin therapy, despite compelling evidence supporting the benefits of this
strategy in those patients for whom oral anti-diabetes agents provide
insufficient control. The development of second-generation insulin analogues
(insulin glargine 300 U/mL and insulin degludec) has provided physicians with
agents that can provide comparable glycaemic control to first-generation insulin,
but with a reduced risk of hypoglycaemia and modes of action suited to once-daily
regimens. These characteristics may help overcome patient and physician concerns
about early insulin use in disease management. To date, there have been no
head-to-head comparisons of second-generation insulins: here we consider recent
real-world evidence and the forthcoming direct comparison in the BRIGHT
randomised controlled study, as presented at the recent 11(th) International
Conference on Advanced Technologies & Treatments for Diabetes (ATTD) 2018.