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Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis
Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and
Review of the Literature
#MMPMID29971178
Niimi N
; Miyashita T
; Tanji K
; Hirai T
; Watanabe K
; Ikeda K
; Morimoto S
; Sekigawa I
Case Rep Rheumatol
2018[]; 2018
(?): 9682801
PMID29971178
show ga
A 57-year-old Japanese man was admitted to the hospital with back pain and fever,
multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests
performed at admission showed an increased proteinase 3 anti-neutrophil
cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic lung biopsy
was performed; pathologic examination showed granulation tissue with necrosis and
multinucleated giant cells. The diagnosis of granulomatosis with polyangiitis
(GPA) was confirmed on the basis of the clinical presentation, laboratory
findings, and lung biopsy. All symptoms were ameliorated, and the serum level of
PR3-ANCA declined following treatment with prednisolone and cyclophosphamide.
Although the association of GPA with AAA is rare, GPA may be included among the
large vessel vasculitides that can give rise to aortic aneurysm.