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2018 ; 7
(6
): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
1399 H&E-stained sentinel lymph node sections of breast cancer patients: the
CAMELYON dataset
#MMPMID29860392
Litjens G
; Bandi P
; Ehteshami Bejnordi B
; Geessink O
; Balkenhol M
; Bult P
; Halilovic A
; Hermsen M
; van de Loo R
; Vogels R
; Manson QF
; Stathonikos N
; Baidoshvili A
; van Diest P
; Wauters C
; van Dijk M
; van der Laak J
Gigascience
2018[Jun]; 7
(6
): ä PMID29860392
show ga
BACKGROUND: The presence of lymph node metastases is one of the most important
factors in breast cancer prognosis. The most common way to assess regional lymph
node status is the sentinel lymph node procedure. The sentinel lymph node is the
most likely lymph node to contain metastasized cancer cells and is excised,
histopathologically processed, and examined by a pathologist. This tedious
examination process is time-consuming and can lead to small metastases being
missed. However, recent advances in whole-slide imaging and machine learning have
opened an avenue for analysis of digitized lymph node sections with computer
algorithms. For example, convolutional neural networks, a type of
machine-learning algorithm, can be used to automatically detect cancer metastases
in lymph nodes with high accuracy. To train machine-learning models, large,
well-curated datasets are needed. RESULTS: We released a dataset of 1,399
annotated whole-slide images (WSIs) of lymph nodes, both with and without
metastases, in 3 terabytes of data in the context of the CAMELYON16 and
CAMELYON17 Grand Challenges. Slides were collected from five medical centers to
cover a broad range of image appearance and staining variations. Each WSI has a
slide-level label indicating whether it contains no metastases, macro-metastases,
micro-metastases, or isolated tumor cells. Furthermore, for 209 WSIs, detailed
hand-drawn contours for all metastases are provided. Last, open-source software
tools to visualize and interact with the data have been made available.
CONCLUSIONS: A unique dataset of annotated, whole-slide digital histopathology
images has been provided with high potential for re-use.