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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Kidney+J
2018 ; 11
(3
): 406-412
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Controversies in the management of the haemodialysis-related arteriovenous
fistula following kidney transplantation
#MMPMID29992020
Vanderweckene P
; Weekers L
; Lancellotti P
; Jouret F
Clin Kidney J
2018[Jun]; 11
(3
): 406-412
PMID29992020
show ga
Arteriovenous fistula (AVF) is regarded as the best vascular access for chronic
haemodialysis (HD). Still, AVF inherently causes significant haemodynamic
changes. Although the necessity for vascular access despite its putative
cardiovascular complications favours AVF creation in patients under chronic HD,
one may question whether sustaining a functional AVF after successful kidney
transplantation extends the haemodynamic threat. Small prospective series suggest
that AVF ligation causes rapid and sustained reduction in left ventricular
hypertrophy. Still, the benefits of such a cardiac remodelling in long-terms of
cardiovascular morbi-mortality still need to be proven. Furthermore, the
elevation of diastolic blood pressure and arterial stiffness caused by AVF
ligation may blunt the expected cardio-protection. Finally, the closure of a
functioning AVF may accelerate the decline of kidney graft function. As a whole,
the current management of a functioning AVF in kidney transplant recipients
remains controversial and does not rely on strong evidence-based data. The
individual risk of graft dysfunction and a return to chronic HD also needs to be
balanced. Careful pre-operative functional assessments, including
cardio-pulmonary testing and estimated glomerular filtration rate slope
estimation, may help better selection of who might benefit the most from AVF
closure. Large-scale prospective, ideally multi-centric, trials are essentially
needed.