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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Kidney+J 2018 ; 11 (3): 422-8 Nephropedia Template TP
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The utility of phospholipase A2 receptor autoantibody in membranous nephropathy after kidney transplantation #MMPMID29988247
Xipell M; Rodas LM; Villarreal J; Molina A; Reinoso-Moreno J; Blasco M; Poch E; Diekmann F; Campistol JM; Quintana LF
Clin Kidney J 2018[Jun]; 11 (3): 422-8 PMID29988247show ga
Membranous nephropathy (MN) is estimated to cause end-stage renal disease in ??5% of patients, in whom renal transplantation is the therapy of choice. Among patients receiving a transplant for MN, the disease will recur in the graft in 30?50%; among these, graft loss will occur in 50% within 10 years. Several studies have suggested that phospholipase A2 receptor autoantibody (aPLA2R) levels before transplantation might be useful in predicting recurrence, and their titration after transplantation is clinically relevant to assess the risk of recurrence and progression, to guide treatment indications and to monitor treatment response. In this review we describe the evolving role of aPLA2R as a biomarker in primary MN and its current usefulness in predicting recurrence of this autoimmune podocytopathy after renal transplantation.