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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Kidney+J
2018 ; 11
(3
): 422-428
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The utility of phospholipase A2 receptor autoantibody in membranous nephropathy
after kidney transplantation
#MMPMID29988247
Xipell M
; Rodas LM
; Villarreal J
; Molina A
; Reinoso-Moreno J
; Blasco M
; Poch E
; Diekmann F
; Campistol JM
; Quintana LF
Clin Kidney J
2018[Jun]; 11
(3
): 422-428
PMID29988247
show ga
Membranous nephropathy (MN) is estimated to cause end-stage renal disease in ??5%
of patients, in whom renal transplantation is the therapy of choice. Among
patients receiving a transplant for MN, the disease will recur in the graft in
30-50%; among these, graft loss will occur in 50% within 10 years. Several
studies have suggested that phospholipase A2 receptor autoantibody (aPLA2R)
levels before transplantation might be useful in predicting recurrence, and their
titration after transplantation is clinically relevant to assess the risk of
recurrence and progression, to guide treatment indications and to monitor
treatment response. In this review we describe the evolving role of aPLA2R as a
biomarker in primary MN and its current usefulness in predicting recurrence of
this autoimmune podocytopathy after renal transplantation.