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10.1007/s00417-018-3945-5 http://scihub22266oqcxt.onion/10.1007/s00417-018-3945-5 C6006239!6006239!29520478     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Graefes+Arch+Clin+Exp+Ophthalmol 2018 ; 256 (7): 1257-64 Nephropedia Template TP {{tp|p=29520478|t=2018. Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine |pdf=|usr=}}{{29520478}} gab.com Text Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine JO: Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=29520478 #FOAvip Purpose: To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography. Methods: This is a prospective, non-randomized, comparative cohort study. We studied the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute. After division by the signal strength (SS), we compared the responses of peripapillary VD/SS and PLFI/unit area (UA)/SS to topical eye drops in eyes with primary open-angle glaucoma (POAG) and ocular hypertension (OH). Results: In the superficial peripapillary retina, VD/SS increased significantly in the ripasudil-treated eyes (12.5?±?21.7%, P?=?0.018), but not in the brimonidine-treated eyes (??2.0?±?13.8%, P?=?0.484). In the deeper area of the optic disc, the changes in the PLFI/UA/SS in the brimonidine-treated eyes (+?0.9?±?8.9%, P?=?1.00) and ripasudil-treated eyes (??1.3?±?8.5%, P?=?0.241) were not significant. Multivariate discriminant analysis showed that the change in the peripapillary VD/SS was the most important parameter (P?=?0.0186) for differentiating ripasudil- and brimonidine-treated eyes. Conclusions: The topical ROCK inhibitor ripasudil enhanced the peripapillary VD in POAG and OH, whereas the alpha-2 agonist brimonidine did not. The PLFI did not respond to either drug. Electronic supplementary material: The online version of this article (10.1007/s00417-018-3945-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine ????Graefes Arch Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=29520478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29520478 #FOAvip English Wikipedia <ref>{{Cite pmid|29520478}}</ref> Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine #MMPMID29520478 Chihara E; Dimitrova G; Chihara T Graefes Arch Clin Exp Ophthalmol 2018[]; 256 (7): 1257-64 PMID29520478show ga Purpose: To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography. Methods: This is a prospective, non-randomized, comparative cohort study. We studied the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute. After division by the signal strength (SS), we compared the responses of peripapillary VD/SS and PLFI/unit area (UA)/SS to topical eye drops in eyes with primary open-angle glaucoma (POAG) and ocular hypertension (OH). Results: In the superficial peripapillary retina, VD/SS increased significantly in the ripasudil-treated eyes (12.5?±?21.7%, P?=?0.018), but not in the brimonidine-treated eyes (??2.0?±?13.8%, P?=?0.484). In the deeper area of the optic disc, the changes in the PLFI/UA/SS in the brimonidine-treated eyes (+?0.9?±?8.9%, P?=?1.00) and ripasudil-treated eyes (??1.3?±?8.5%, P?=?0.241) were not significant. Multivariate discriminant analysis showed that the change in the peripapillary VD/SS was the most important parameter (P?=?0.0186) for differentiating ripasudil- and brimonidine-treated eyes. Conclusions: The topical ROCK inhibitor ripasudil enhanced the peripapillary VD in POAG and OH, whereas the alpha-2 agonist brimonidine did not. The PLFI did not respond to either drug. Electronic supplementary material: The online version of this article (10.1007/s00417-018-3945-5) contains supplementary material, which is available to authorized users. äIncrease in the OCT angiographic peripapillary vessel density by ROCK (epmc).pdf DeepDyve Pubget Overpricing