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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biol+Inorg+Chem
2018 ; 23
(4
): 581-596
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Iron-sulfur clusters biogenesis by the SUF machinery: close to the molecular
mechanism understanding
#MMPMID29280002
Pérard J
; Ollagnier de Choudens S
J Biol Inorg Chem
2018[Jun]; 23
(4
): 581-596
PMID29280002
show ga
Iron-sulfur clusters (Fe-S) are amongst the most ancient and versatile inorganic
cofactors in nature which are used by proteins for fundamental biological
processes. Multiprotein machineries (NIF, ISC, SUF) exist for Fe-S cluster
biogenesis which are mainly conserved from bacteria to human. SUF system
(sufABCDSE operon) plays a general role in many bacteria under conditions of iron
limitation or oxidative stress. In this mini-review, we will summarize the
current understanding of the molecular mechanism of Fe-S biogenesis by SUF. The
advances in our understanding of the molecular aspects of SUF originate from
biochemical, biophysical and recent structural studies. Combined with recent in
vivo experiments, the understanding of the Fe-S biogenesis mechanism considerably
moved forward.