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10.1126/scisignal.aaq1060 http://scihub22266oqcxt.onion/10.1126/scisignal.aaq1060 C5999017!5999017!29382784     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2018 ; 11 (515): ä Nephropedia Template TP {{tp|p=29382784|t=2018. KIF22 co-ordinates CAR and EGFR dynamics to promote cancer cell proliferation |pdf=|usr=}}{{29382784}} gab.com Text KIF22 co-ordinates CAR and EGFR dynamics to promote cancer cell proliferation JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=29382784 #FOAvip The Coxsackie and Adenovirus Receptor (CAR) is a transmembrane receptor that plays a key role in cell-cell adhesion. CAR is found in normal epithelial cells and is increased in abundance in various human tumors, including lung carcinomas. Here, we investigated the potential mechanisms by which CAR contributes to cancer cell growth and found that depletion of CAR in human lung cancer cells reduced anchorage-independent growth, epidermal growth factor (EGF)?dependent proliferation, and tumor growth in vivo. EGF induced the phosphorylation of CAR and its subsequent relocalization to cell junctions through the activation of the kinase PKC?. EGF promoted the binding of CAR to the chromokinesin KIF22. KIF22-dependent regulation of microtubule dynamics led to delayed EGFR internalization, enhanced EGFR signaling, and coordination of CAR dynamics at cell-cell junctions. These data suggest a role for KIF22 in the coordination of membrane receptors and provide potential new therapeutic strategies to combat lung tumor growth. Twit Text FOAVip KIF22 co-ordinates CAR and EGFR dynamics to promote cancer cell proliferation ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=29382784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29382784 #FOAvip English Wikipedia <ref>{{Cite pmid|29382784}}</ref> KIF22 co-ordinates CAR and EGFR dynamics to promote cancer cell proliferation #MMPMID29382784 Pike R; Ortiz-Zapater E; Lumicisi B; Santis G; Parsons M Sci Signal 2018[Jan]; 11 (515): ä PMID29382784show ga The Coxsackie and Adenovirus Receptor (CAR) is a transmembrane receptor that plays a key role in cell-cell adhesion. CAR is found in normal epithelial cells and is increased in abundance in various human tumors, including lung carcinomas. Here, we investigated the potential mechanisms by which CAR contributes to cancer cell growth and found that depletion of CAR in human lung cancer cells reduced anchorage-independent growth, epidermal growth factor (EGF)?dependent proliferation, and tumor growth in vivo. EGF induced the phosphorylation of CAR and its subsequent relocalization to cell junctions through the activation of the kinase PKC?. EGF promoted the binding of CAR to the chromokinesin KIF22. KIF22-dependent regulation of microtubule dynamics led to delayed EGFR internalization, enhanced EGFR signaling, and coordination of CAR dynamics at cell-cell junctions. These data suggest a role for KIF22 in the coordination of membrane receptors and provide potential new therapeutic strategies to combat lung tumor growth. äKIF22 co-ordinates CAR and EGFR dynamics to promote cancer cell prolif(epmc).pdf DeepDyve Pubget Overpricing