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10.1155/2018/7373921 http://scihub22266oqcxt.onion/10.1155/2018/7373921 C5994578!5994578 !29997451     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29997451 &cmd=llinks): Failed to open stream: HTTP request failed! 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Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |pdf=|usr=}}{{29997451 }} gab.com Text Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29997451 #FOAvip Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1? expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1?-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1? secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context. Twit Text FOAVip Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29997451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29997451 #FOAvip English Wikipedia <ref>{{Cite pmid|29997451 }}</ref> Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression #MMPMID29997451 Cubillos-Zapata C ; Hernández-Jiménez E ; Avendaño-Ortiz J ; Toledano V ; Varela-Serrano A ; Fernández-Navarro I ; Casitas R ; Carpio C ; Aguirre LA ; García-Río F ; López-Collazo E Mediators Inflamm 2018[]; 2018 (ä): 7373921 PMID29997451 show ga Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1? expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1?-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1? secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context. |Adult [MESH] |Aged [MESH] |Biomarkers/metabolism [MESH] |Cell Survival/physiology [MESH] |Cells, Cultured [MESH] |Female [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH] |Leukocytes, Mononuclear/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Oxygen/metabolism [MESH] |Prospective Studies [MESH] |Sleep Apnea, Obstructive/*metabolism [MESH] |Spheroids, Cellular/metabolism [MESH]Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endo(epmc).pdf DeepDyve Pubget Overpricing