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Artificial Liver and Renal Support System for Cynomolgus Monkeys with
Surgery-Induced Acute Renal Failure: A Preclinical Study
#MMPMID29992160
Feng L
; He G
; Cai L
; Fu C
; Li Y
; Weng J
; Huo X
; Peng Q
; Gao Y
Biomed Res Int
2018[]; 2018
(?): 7456898
PMID29992160
show ga
Renal dysfunction is one of the most common complications of liver cirrhosis and
is associated with increased morbidity and mortality. However, no available
technology can simultaneously support liver and renal function in these patients.
The aim of this study was to evaluate the safety and efficacy of an artificial
liver and renal support system in cynomolgus monkeys with surgery-induced ARF.
The ARF model was established by ligature of bilateral renal arteries in eight
cynomolgus monkeys, which were randomly divided into a treatment group (n = 4)
and control group (n = 4). Biochemical indexes were determined before and after
surgery. Blood endotoxin levels, biochemical indexes, and bacterial cultures were
assessed at 0, 3, and 6?h during treatment. System pressures and vital signs were
recorded at 1?h intervals. Pathological examination was performed after death.
ARF was successfully established, based on significant elevation of biochemical
indexes and pathological examination. The treatment group had significantly
reduced biochemical indexes relative to the control group. Measurement of blood
endotoxins and aerobic and anaerobic bacteria cultures indicated no bacterial
growth. The system pressures and vital signs were stable during treatment. The
results indicate that our support system for the treatment of cynomolgus monkeys
with surgery-induced acute renal failure is safe and effective.
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