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10.1016/j.imbio.2017.07.002 http://scihub22266oqcxt.onion/10.1016/j.imbio.2017.07.002 C5990420!5990420!28734654     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunobiology 2017 ; 222 (11): 979-88 Nephropedia Template TP {{tp|p=28734654|t=2017. Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication |pdf=|usr=}}{{28734654}} gab.com Text Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=28734654 #FOAvip Schlafen (SLFN) proteins have been suggested to play important functions in cell proliferation and immune cell development. In this study, we determined the antiviral activities of putative RNA-helicase domain-containing SLFN14. Murine SLFN14 expression was specifically induced by TLR3-mediated pathways and type I interferon (IFN) in RAW264.7 mouse macrophages. To examine the role of SLFN during viral infection, cells were infected with either wild-type PR8 or delNS1/PR8 virus. SLFN14 expression was specifically induced following influenza virus infection. Overexpression of SLFN14 in A549 cells reduced viral replication, whereas knockdown of SLFN14 in RAW264.7 cells enhanced viral titers. Furthermore, SLFN14 promoted the delay in viral NP translocation from cytoplasm to nucleus and enhanced RIG-I-mediated IFN-? signaling. In addition, SLFN14 over-expression promoted antiviral activity against varicella zoster virus (VZV), a DNA virus. In conclusion, our data suggest that SLFN14 is a novel antiviral factor for both DNA and RNA viruses. Twit Text FOAVip Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=28734654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28734654 #FOAvip English Wikipedia <ref>{{Cite pmid|28734654}}</ref> Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication #MMPMID28734654 Seong RK; Seo Sw; Kim JA; Fletcher SJ; Morgan NV; Kumar M; Choi YK; Shin OS Immunobiology 2017[Nov]; 222 (11): 979-88 PMID28734654show ga Schlafen (SLFN) proteins have been suggested to play important functions in cell proliferation and immune cell development. In this study, we determined the antiviral activities of putative RNA-helicase domain-containing SLFN14. Murine SLFN14 expression was specifically induced by TLR3-mediated pathways and type I interferon (IFN) in RAW264.7 mouse macrophages. To examine the role of SLFN during viral infection, cells were infected with either wild-type PR8 or delNS1/PR8 virus. SLFN14 expression was specifically induced following influenza virus infection. Overexpression of SLFN14 in A549 cells reduced viral replication, whereas knockdown of SLFN14 in RAW264.7 cells enhanced viral titers. Furthermore, SLFN14 promoted the delay in viral NP translocation from cytoplasm to nucleus and enhanced RIG-I-mediated IFN-? signaling. In addition, SLFN14 over-expression promoted antiviral activity against varicella zoster virus (VZV), a DNA virus. In conclusion, our data suggest that SLFN14 is a novel antiviral factor for both DNA and RNA viruses. äSchlafen 14 (SLFN14) is a novel antiviral factor involved in the contr(epmc).pdf DeepDyve Pubget Overpricing