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10.1002/jso.24643

http://scihub22266oqcxt.onion/10.1002/jso.24643
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C5989710!5989710!28605029
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suck abstract from ncbi


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pmid28605029      J+Surg+Oncol 2017 ; 116 (1): 7-15
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  • The pancreatic cancer microenvironment: A True Double Agent #MMPMID28605029
  • Melstrom L; Salazar MD; Diamond DJ
  • J Surg Oncol 2017[Jul]; 116 (1): 7-15 PMID28605029show ga
  • The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy and Vitamin D. The developing clinical therapeutics will be reviewed.
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