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10.1186/s40425-018-0361-7 http://scihub22266oqcxt.onion/10.1186/s40425-018-0361-7 C5987486!5987486 !29866197     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29866197 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29866197 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunother+Cancer 2018 ; 6 (1 ): 46 Nephropedia Template TP {{tp|p=29866197 |t=2018. Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination |pdf=|usr=}}{{29866197 }} gab.com Text Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination JO: J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29866197 #FOAvip Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation therapy (RT) has been shown to enhance the priming and effector phases of the antitumor T-cell response rendering it an attractive therapy to combine with PD-1/PD-L1 inhibitors. Preclinical data support the rational combination of the 2 modalities and has paved way for the clinical development of the combination across a spectrum of cancers. In this review, we highlight the preclinical and clinical development of combined RT and PD-1/PD-L1 blockade to date. In addition to a comprehensive evaluation of available safety and efficacy data, we discuss important points of consideration in clinical trial design for this promising combination. Twit Text FOAVip Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination ????J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29866197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29866197 #FOAvip English Wikipedia <ref>{{Cite pmid|29866197 }}</ref> Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination #MMPMID29866197 Gong J ; Le TQ ; Massarelli E ; Hendifar AE ; Tuli R J Immunother Cancer 2018[Jun]; 6 (1 ): 46 PMID29866197 show ga Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation therapy (RT) has been shown to enhance the priming and effector phases of the antitumor T-cell response rendering it an attractive therapy to combine with PD-1/PD-L1 inhibitors. Preclinical data support the rational combination of the 2 modalities and has paved way for the clinical development of the combination across a spectrum of cancers. In this review, we highlight the preclinical and clinical development of combined RT and PD-1/PD-L1 blockade to date. In addition to a comprehensive evaluation of available safety and efficacy data, we discuss important points of consideration in clinical trial design for this promising combination. |Animals [MESH] |Combined Modality Therapy/*methods [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Mice [MESH] |Neoplasms/*drug therapy/*radiotherapy [MESH] |Programmed Cell Death 1 Receptor/*antagonists & inhibitors [MESH]Radiation therapy and PD-1/PD-L1 blockade: the clinical development of(epmc).pdf DeepDyve Pubget Overpricing