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10.1016/j.jot.2015.08.001 http://scihub22266oqcxt.onion/10.1016/j.jot.2015.08.001 C5986999!5986999!30035063     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Orthop+Translat 2016 ; 4 (ä): 28-34 Nephropedia Template TP {{tp|p=30035063|t=2016. Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing |pdf=|usr=}}{{30035063}} gab.com Text Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing JO: J Orthop Translat http://www.kidney.de/pget.php?&tw=1&pmid=30035063 #FOAvip Bone morphogenetic proteins (BMPs) are a group of signalling molecules that belong to the transforming growth factor-? superfamily of proteins. Initially identified for their ability to induce bone formation, recent advances in the understanding of cellular and molecular mechanisms regarding BMPs have led to the use of the growth factor to accelerate bone healing. Recent clinical trials have demonstrated that BMPs, BMP-7 in particular, may present an alternative line of treatment other than the gold standard, autogenous bone grafting, in the treatment of fracture nonunion. We performed a literature search in September 2014 of PubMed and Embase using search terms, including ?bone morphogenetic proteins?, ?BMP-7?, ?non-union?, ?fracture healing? and ?cost-effectiveness?, reviewing the efficacy, safety, and cost of treatment of nonunions with BMP-7. The authors further canvassed the reference lists of selected articles and used online search tools, such as Google Scholar. BMP-7 uses both the canonical and noncanonical signalling pathways. The treatment of fracture nonunion with recombinant human BMP-7 (rhBMP-7) has a comparable efficacy with that of autogenous bone grafting with an average union rate of 87% compared with 93% for bone grafting. Furthermore, fewer complications have been described with the use of rhBMP-7 compared with traditional bone grafting. We describe the signalling pathways that BMP-7 uses to exert its effect on bone. In nonunions, rhBMP-7 has been shown to have a similar efficacy to bone grafting with fewer complications. Twit Text FOAVip Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing ????J Orthop Translat http://www.kidney.de/pget.php?&tw=1&pmid=30035063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30035063 #FOAvip English Wikipedia <ref>{{Cite pmid|30035063}}</ref> Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing #MMPMID30035063 Cecchi S; Bennet SJ; Arora M J Orthop Translat 2016[Jan]; 4 (ä): 28-34 PMID30035063show ga Bone morphogenetic proteins (BMPs) are a group of signalling molecules that belong to the transforming growth factor-? superfamily of proteins. Initially identified for their ability to induce bone formation, recent advances in the understanding of cellular and molecular mechanisms regarding BMPs have led to the use of the growth factor to accelerate bone healing. Recent clinical trials have demonstrated that BMPs, BMP-7 in particular, may present an alternative line of treatment other than the gold standard, autogenous bone grafting, in the treatment of fracture nonunion. We performed a literature search in September 2014 of PubMed and Embase using search terms, including ?bone morphogenetic proteins?, ?BMP-7?, ?non-union?, ?fracture healing? and ?cost-effectiveness?, reviewing the efficacy, safety, and cost of treatment of nonunions with BMP-7. The authors further canvassed the reference lists of selected articles and used online search tools, such as Google Scholar. BMP-7 uses both the canonical and noncanonical signalling pathways. The treatment of fracture nonunion with recombinant human BMP-7 (rhBMP-7) has a comparable efficacy with that of autogenous bone grafting with an average union rate of 87% compared with 93% for bone grafting. Furthermore, fewer complications have been described with the use of rhBMP-7 compared with traditional bone grafting. We describe the signalling pathways that BMP-7 uses to exert its effect on bone. In nonunions, rhBMP-7 has been shown to have a similar efficacy to bone grafting with fewer complications. äBone morphogenetic protein-7: Review of signalling and efficacy in fra(epmc).pdf DeepDyve Pubget Overpricing