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10.1038/s41588-017-0013-8 http://scihub22266oqcxt.onion/10.1038/s41588-017-0013-8 C5985926!5985926 !29255261     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29255261 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2018 ; 50 (1 ): 6-11 Nephropedia Template TP {{tp|p=29255261 |t=2018. Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism |pdf=|usr=}}{{29255261 }} gab.com Text Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=29255261 #FOAvip Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) (1) ; heritability estimated from twin studies ranges from 30 to 50% (2) , and SNP-based heritability ranges from 6 to 15% (3-6) . Increased neuroticism is associated with poorer mental and physical health (7,8) , translating to high economic burden (9) . Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic loci (3,4) . Here we report 116 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at P?<?0.00045 in an unrelated cohort (N?=?122,867). Genetic signals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (r (g)?=?0.82, standard error (s.e.)?=?0.03), major depressive disorder (MDD; r (g)?=?0.69, s.e.?=?0.07) and subjective well-being (r (g)?=?-0.68, s.e.?=?0.03) alongside other mental health traits. These discoveries significantly advance understanding of neuroticism and its association with MDD. Twit Text FOAVip Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=29255261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29255261 #FOAvip English Wikipedia <ref>{{Cite pmid|29255261 }}</ref> Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism #MMPMID29255261 Luciano M ; Hagenaars SP ; Davies G ; Hill WD ; Clarke TK ; Shirali M ; Harris SE ; Marioni RE ; Liewald DC ; Fawns-Ritchie C ; Adams MJ ; Howard DM ; Lewis CM ; Gale CR ; McIntosh AM ; Deary IJ Nat Genet 2018[Jan]; 50 (1 ): 6-11 PMID29255261 show ga Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) (1) ; heritability estimated from twin studies ranges from 30 to 50% (2) , and SNP-based heritability ranges from 6 to 15% (3-6) . Increased neuroticism is associated with poorer mental and physical health (7,8) , translating to high economic burden (9) . Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic loci (3,4) . Here we report 116 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at P? |*Neuroticism [MESH] |*Polymorphism, Single Nucleotide [MESH] |Female [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH]Association analysis in over 329,000 individuals identifies 116 indepe(epmc).pdf DeepDyve Pubget Overpricing