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10.18632/oncoscience.413 http://scihub22266oqcxt.onion/10.18632/oncoscience.413 C5978448!5978448 !29854879     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29854879 &cmd=llinks): Failed to open stream: HTTP request failed! 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Non-selective beta blockers inhibit angiosarcoma cell viability and increase progression free- and overall-survival in patients diagnosed with metastatic angiosarcoma |pdf=|usr=}}{{29854879 }} gab.com Text Non-selective beta blockers inhibit angiosarcoma cell viability and increase progression free- and overall-survival in patients diagnosed with metastatic angiosarcoma JO: Oncoscience http://www.kidney.de/pget.php?&tw=1&pmid=29854879 #FOAvip Patients with metastatic angiosarcoma undergoing chemotherapy, radiation, and/or surgery experience a median progression free survival of less than 6 months and a median overall survival of less than 12 months. Given the aggressive nature of this cancer, angiosarcoma clinical responses to chemotherapy or targeted therapeutics are generally very poor. Inhibition of beta adrenergic receptor (?-AR) signaling has recently been shown to decrease angiosarcoma tumor cell viability, abrogate tumor growth in mouse models, and decrease proliferation rates in preclinical and clinical settings. In the current study we used cell and animal tumor models to show that ?-AR antagonism abrogates mitogenic signaling and reduces angiosarcoma tumor cell viability, and these molecular alterations translated into patient tumors. We demonstrated that non-selective ?-AR antagonists are superior to selective ?-AR antagonists at inhibiting angiosarcoma cell viability. A prospective analysis of non- selective ?-AR antagonists in a single arm clinical study of metastatic angiosarcoma patients revealed that incorporation of either propranolol or carvedilol into patients' treatment regimens leads to a median progression free and overall survival of 9 and 36 months, respectively. These data suggest that incorporation of non-selective ?-AR antagonists into existing therapies against metastatic angiosarcoma can enhance clinical outcomes. Twit Text FOAVip Non-selective beta blockers inhibit angiosarcoma cell viability and increase progression free- and overall-survival in patients diagnosed with metastatic angiosarcoma ????Oncoscience http://www.kidney.de/pget.php?&tw=1&pmid=29854879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29854879 #FOAvip English Wikipedia <ref>{{Cite pmid|29854879 }}</ref> Non-selective beta blockers inhibit angiosarcoma cell viability and increase progression free- and overall-survival in patients diagnosed with metastatic angiosarcoma #MMPMID29854879 Amaya CN ; Perkins M ; Belmont A ; Herrera C ; Nasrazadani A ; Vargas A ; Khayou T ; Montoya A ; Ballou Y ; Galvan D ; Rivas A ; Rains S ; Patel L ; Ortega V ; Lopez C ; Chow W ; Dickerson EB ; Bryan BA Oncoscience 2018[Mar]; 5 (3-4 ): 109-119 PMID29854879 show ga Patients with metastatic angiosarcoma undergoing chemotherapy, radiation, and/or surgery experience a median progression free survival of less than 6 months and a median overall survival of less than 12 months. Given the aggressive nature of this cancer, angiosarcoma clinical responses to chemotherapy or targeted therapeutics are generally very poor. Inhibition of beta adrenergic receptor (?-AR) signaling has recently been shown to decrease angiosarcoma tumor cell viability, abrogate tumor growth in mouse models, and decrease proliferation rates in preclinical and clinical settings. In the current study we used cell and animal tumor models to show that ?-AR antagonism abrogates mitogenic signaling and reduces angiosarcoma tumor cell viability, and these molecular alterations translated into patient tumors. We demonstrated that non-selective ?-AR antagonists are superior to selective ?-AR antagonists at inhibiting angiosarcoma cell viability. A prospective analysis of non- selective ?-AR antagonists in a single arm clinical study of metastatic angiosarcoma patients revealed that incorporation of either propranolol or carvedilol into patients' treatment regimens leads to a median progression free and overall survival of 9 and 36 months, respectively. These data suggest that incorporation of non-selective ?-AR antagonists into existing therapies against metastatic angiosarcoma can enhance clinical outcomes. äNon-selective beta blockers inhibit angiosarcoma cell viability and in(epmc).pdf DeepDyve Pubget Overpricing