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10.3390/genes9050241 http://scihub22266oqcxt.onion/10.3390/genes9050241 C5977181!5977181!29751586     free     free     free       Genes+(Basel) 2018 ; 9 (5): ä Nephropedia Template TP {{tp|p=29751586|t=2018. Telomere Maintenance Mechanisms in Cancer |pdf=|usr=}}{{29751586}} gab.com Text Telomere Maintenance Mechanisms in Cancer JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29751586 #FOAvip Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was generated, and different TMMs were reported and explained in detail, benefiting from genome-scale studies of major importance. In this review, we address seven different TMMs in tumour cells: mutations of the TERT promoter (TERTp), amplification of the genes TERT and TERC, polymorphic variants of the TERT gene and of its promoter, rearrangements of the TERT gene, epigenetic changes, ALT, and non-defined TMM (NDTMM). We gathered information from over fifty thousand patients reported in 288 papers in the last years. This wide data collection enabled us to portray, by organ/system and histotypes, the prevalence of TERTp mutations, TERT and TERC amplifications, and ALT in human tumours. Based on this information, we discuss the putative future clinical impact of the aforementioned mechanisms on the malignant transformation process in different setups, and provide insights for screening, prognosis, and patient management stratification. Twit Text FOAVip Telomere Maintenance Mechanisms in Cancer ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29751586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29751586 #FOAvip English Wikipedia <ref>{{Cite pmid|29751586}}</ref> Telomere Maintenance Mechanisms in Cancer #MMPMID29751586 Bordeira Gaspar T; Sá A; Lopes JM; Sobrinho-Simões M; Soares P; Vinagre J Genes (Basel) 2018[May]; 9 (5): ä PMID29751586show ga Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was generated, and different TMMs were reported and explained in detail, benefiting from genome-scale studies of major importance. In this review, we address seven different TMMs in tumour cells: mutations of the TERT promoter (TERTp), amplification of the genes TERT and TERC, polymorphic variants of the TERT gene and of its promoter, rearrangements of the TERT gene, epigenetic changes, ALT, and non-defined TMM (NDTMM). We gathered information from over fifty thousand patients reported in 288 papers in the last years. This wide data collection enabled us to portray, by organ/system and histotypes, the prevalence of TERTp mutations, TERT and TERC amplifications, and ALT in human tumours. Based on this information, we discuss the putative future clinical impact of the aforementioned mechanisms on the malignant transformation process in different setups, and provide insights for screening, prognosis, and patient management stratification. äTelomere Maintenance Mechanisms in Cancer (epmc).pdf DeepDyve Pubget Overpricing