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10.3390/cancers10050152 http://scihub22266oqcxt.onion/10.3390/cancers10050152 C5977125!5977125!29883412     free     free     free       Cancers+(Basel) 2018 ; 10 (5): ä Nephropedia Template TP {{tp|p=29883412|t=2018. 40 Years of Research Put p53 in Translation |pdf=|usr=}}{{29883412}} gab.com Text 40 Years of Research Put p53 in Translation JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29883412 #FOAvip Since its discovery in 1979, p53 has shown multiple facets. Initially the tumor suppressor p53 protein was considered as a stress sensor able to maintain the genome integrity by regulating transcription of genes involved in cell cycle arrest, apoptosis and DNA repair. However, it rapidly came into light that p53 regulates gene expression to control a wider range of biological processes allowing rapid cell adaptation to environmental context. Among them, those related to cancer have been extensively documented. In addition to its role as transcription factor, scattered studies reported that p53 regulates miRNA processing, modulates protein activity by direct interaction or exhibits RNA-binding activity, thus suggesting a role of p53 in regulating several layers of gene expression not restricted to transcription. After 40 years of research, it appears more and more clearly that p53 is strongly implicated in translational regulation as well as in the control of the production and activity of the translational machinery. Translation control of specific mRNAs could provide yet unsuspected capabilities to this well-known guardian of the genome. Twit Text FOAVip 40 Years of Research Put p53 in Translation ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29883412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29883412 #FOAvip English Wikipedia <ref>{{Cite pmid|29883412}}</ref> 40 Years of Research Put p53 in Translation #MMPMID29883412 Marcel V; Nguyen Van Long F; Diaz JJ Cancers (Basel) 2018[May]; 10 (5): ä PMID29883412show ga Since its discovery in 1979, p53 has shown multiple facets. Initially the tumor suppressor p53 protein was considered as a stress sensor able to maintain the genome integrity by regulating transcription of genes involved in cell cycle arrest, apoptosis and DNA repair. However, it rapidly came into light that p53 regulates gene expression to control a wider range of biological processes allowing rapid cell adaptation to environmental context. Among them, those related to cancer have been extensively documented. In addition to its role as transcription factor, scattered studies reported that p53 regulates miRNA processing, modulates protein activity by direct interaction or exhibits RNA-binding activity, thus suggesting a role of p53 in regulating several layers of gene expression not restricted to transcription. After 40 years of research, it appears more and more clearly that p53 is strongly implicated in translational regulation as well as in the control of the production and activity of the translational machinery. Translation control of specific mRNAs could provide yet unsuspected capabilities to this well-known guardian of the genome. ä40 Years of Research Put p53 in Translation (epmc).pdf DeepDyve Pubget Overpricing