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10.1038/s41598-018-26371-y http://scihub22266oqcxt.onion/10.1038/s41598-018-26371-y C5976677!5976677 !29849047     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29849047 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 8398 Nephropedia Template TP {{tp|p=29849047 |t=2018. Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration |pdf=|usr=}}{{29849047 }} gab.com Text Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29849047 #FOAvip Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric muscle loss (VML). Therapeutic approaches involving acellular matrices represent an emerging and promising strategy to promote regeneration of skeletal muscle following injury. Here we investigated the ability of three different decellularised skeletal muscle scaffolds to support muscle regeneration in a xenogeneic immune-competent model of VML, in which the EDL muscle was surgically resected. All implanted acellular matrices, used to replace the resected muscles, were able to generate functional artificial muscles by promoting host myogenic cell migration and differentiation, as well as nervous fibres, vascular networks, and satellite cell (SC) homing. However, acellular tissue mainly composed of extracellular matrix (ECM) allowed better myofibre three-dimensional (3D) organization and the restoration of SC pool, when compared to scaffolds which also preserved muscular cytoskeletal structures. Finally, we showed that fibroblasts are indispensable to promote efficient migration and myogenesis by muscle stem cells across the scaffolds in vitro. This data strongly support the use of xenogeneic acellular muscles as device to treat VML conditions in absence of donor cell implementation, as well as in vitro model for studying cell interplay during myogenesis. Twit Text FOAVip Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29849047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29849047 #FOAvip English Wikipedia <ref>{{Cite pmid|29849047 }}</ref> Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration #MMPMID29849047 Urciuolo A ; Urbani L ; Perin S ; Maghsoudlou P ; Scottoni F ; Gjinovci A ; Collins-Hooper H ; Loukogeorgakis S ; Tyraskis A ; Torelli S ; Germinario E ; Fallas MEA ; Julia-Vilella C ; Eaton S ; Blaauw B ; Patel K ; De Coppi P Sci Rep 2018[May]; 8 (1 ): 8398 PMID29849047 show ga Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric muscle loss (VML). Therapeutic approaches involving acellular matrices represent an emerging and promising strategy to promote regeneration of skeletal muscle following injury. Here we investigated the ability of three different decellularised skeletal muscle scaffolds to support muscle regeneration in a xenogeneic immune-competent model of VML, in which the EDL muscle was surgically resected. All implanted acellular matrices, used to replace the resected muscles, were able to generate functional artificial muscles by promoting host myogenic cell migration and differentiation, as well as nervous fibres, vascular networks, and satellite cell (SC) homing. However, acellular tissue mainly composed of extracellular matrix (ECM) allowed better myofibre three-dimensional (3D) organization and the restoration of SC pool, when compared to scaffolds which also preserved muscular cytoskeletal structures. Finally, we showed that fibroblasts are indispensable to promote efficient migration and myogenesis by muscle stem cells across the scaffolds in vitro. This data strongly support the use of xenogeneic acellular muscles as device to treat VML conditions in absence of donor cell implementation, as well as in vitro model for studying cell interplay during myogenesis. |*Cell Movement [MESH] |*Regeneration [MESH] |*Tissue Engineering [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Muscle, Skeletal/*cytology/*physiology [MESH] |Rats [MESH]Decellularised skeletal muscles allow functional muscle regeneration b(epmc).pdf DeepDyve Pubget Overpricing