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10.1038/mi.2017.117 http://scihub22266oqcxt.onion/10.1038/mi.2017.117 C5976511!5976511!29363670     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2018 ; 11 (3): 741-51 Nephropedia Template TP {{tp|p=29363670|t=2018. Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkB? in Airway Epithelial Cells to Reduce Pulmonary Inflammation |pdf=|usr=}}{{29363670}} gab.com Text Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkB in Airway Epithelial Cells to Reduce Pulmonary Inflammation JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29363670 #FOAvip IFN-? is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-? rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared with noxa+/+ mice. Noxa expression blocked TNF-?-induced nuclear translocation of NF-?B and the production of pro-inflammatory cytokines. Noxa did not affect TNF-?-induced I?B? phosphorylation but the degradation of 48-chain-ubiquitylated I?B?. The Cys25 of Noxa was cross-linked with Cys137 of phospho-HSP27 and both proteins were required for blocking the degradation of ubiquitylated I?B?. Because, phospho-HSP27 is present in airway epithelial cells and not in fibroblasts or thymocytes, we generated transgenic mice that inducibly expressed Noxa in airway epithelia. These mice showed protection from allergen-induced inflammation and mucous cell metaplasia by blocking nuclear translocation of NF-?B. Further, we identified a Noxa-derived peptide that prolonged degradation of 48-chain-ubiquitylated I?B? blocked nuclear translocation of NF-?B, and reduced allergen-induced inflammation in mice. These results suggest that the anti-inflammatory role of the Noxa protein may be restricted to airway epithelial cells and the use of Noxa for therapy of chronic lung diseases may be associated with reduced side effects. Twit Text FOAVip Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkB in Airway Epithelial Cells to Reduce Pulmonary Inflammation ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29363670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29363670 #FOAvip English Wikipedia <ref>{{Cite pmid|29363670}}</ref> Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkB? in Airway Epithelial Cells to Reduce Pulmonary Inflammation #MMPMID29363670 Zhang C; Jones JT; Chand HS; Wathelet MG; Evans CM; Dickey B; Xiang J; Mebratu YA; Tesfaigzi Y Mucosal Immunol 2018[May]; 11 (3): 741-51 PMID29363670show ga IFN-? is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-? rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared with noxa+/+ mice. Noxa expression blocked TNF-?-induced nuclear translocation of NF-?B and the production of pro-inflammatory cytokines. Noxa did not affect TNF-?-induced I?B? phosphorylation but the degradation of 48-chain-ubiquitylated I?B?. The Cys25 of Noxa was cross-linked with Cys137 of phospho-HSP27 and both proteins were required for blocking the degradation of ubiquitylated I?B?. Because, phospho-HSP27 is present in airway epithelial cells and not in fibroblasts or thymocytes, we generated transgenic mice that inducibly expressed Noxa in airway epithelia. These mice showed protection from allergen-induced inflammation and mucous cell metaplasia by blocking nuclear translocation of NF-?B. Further, we identified a Noxa-derived peptide that prolonged degradation of 48-chain-ubiquitylated I?B? blocked nuclear translocation of NF-?B, and reduced allergen-induced inflammation in mice. These results suggest that the anti-inflammatory role of the Noxa protein may be restricted to airway epithelial cells and the use of Noxa for therapy of chronic lung diseases may be associated with reduced side effects. äNoxa/HSP27 Complex Delays Degradation of Ubiquitylated IkB? in Airway (epmc).pdf DeepDyve Pubget Overpricing