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10.1016/j.molcel.2010.03.016 http://scihub22266oqcxt.onion/10.1016/j.molcel.2010.03.016 C5975946!5975946!20513434     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2010 ; 38 (4): 603-13 Nephropedia Template TP {{tp|p=20513434|t=2010. Molecular maps of the reorganization of genome ? nuclear lamina interactions during differentiation |pdf=|usr=}}{{20513434}} gab.com Text Molecular maps of the reorganization of genome nuclear lamina interactions during differentiation JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=20513434 #FOAvip The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. To visualize this process in molecular detail, we generated high-resolution maps of genome ? nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural precursor cells into terminally differentiated astrocytes. This reveals that a basal chromosome architecture present in embryonic stem cells is cumulatively altered at hundreds of sites during lineage commitment and subsequent terminal differentiation. This remodeling involves both individual transcription units and multi-gene regions, and affects many genes that determine cellular identity. Often, genes that move away from the lamina are concomitantly activated; many others however remain inactive yet become unlocked for activation in a next differentiation step. These results suggest that lamina-genome interactions are widely involved in the control of gene expression programs during lineage commitment and terminal differentiation. Twit Text FOAVip Molecular maps of the reorganization of genome nuclear lamina interactions during differentiation ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=20513434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20513434 #FOAvip English Wikipedia <ref>{{Cite pmid|20513434}}</ref> Molecular maps of the reorganization of genome ? nuclear lamina interactions during differentiation #MMPMID20513434 Peric-Hupkes D; Meuleman W; Pagie L; Bruggeman SW; Solovei I; Brugman W; Gräf S; Flicek P; Kerkhoven RM; van Lohuizen M; Reinders M; Wessels L; van Steensel B Mol Cell 2010[May]; 38 (4): 603-13 PMID20513434show ga The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. To visualize this process in molecular detail, we generated high-resolution maps of genome ? nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural precursor cells into terminally differentiated astrocytes. This reveals that a basal chromosome architecture present in embryonic stem cells is cumulatively altered at hundreds of sites during lineage commitment and subsequent terminal differentiation. This remodeling involves both individual transcription units and multi-gene regions, and affects many genes that determine cellular identity. Often, genes that move away from the lamina are concomitantly activated; many others however remain inactive yet become unlocked for activation in a next differentiation step. These results suggest that lamina-genome interactions are widely involved in the control of gene expression programs during lineage commitment and terminal differentiation. äMolecular maps of the reorganization of genome ? nuclear lamina intera(epmc).pdf DeepDyve Pubget Overpricing