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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Urol 2018 ; 18 (ä): ä Nephropedia Template TP
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Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? #MMPMID29843769
Coelho RWP; Pinho JD; Moreno JS; Garbis DVe O; do Nascimento AMT; Larges JS; Calixto JRR; Ramalho LNZ; da Silva AAM; Nogueira LR; de Moura Feitoza L; Silva GEB
BMC Urol 2018[]; 18 (ä): ä PMID29843769show ga
Background: The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease. Methods: A retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004?2014. Results: The age-standardized incidence was 6.15 per 100,000 and the crude annual incidence was 1.18 per 100,000. More than half (61.1%) of the tumors were histological grades 2 and 3, and 66.4% of tumors were classified as at least stage T2. The average age of patients was 58.6?±?15.7 years (range, 18 to 103 years), with 20.8% of patients ?40 years of age at diagnosis. The vast majority underwent penectomy (93%). Only 41.8% underwent lymphadenectomy, 58 patients (14.8%) received chemotherapy, and 54 patients (13.8%) received radiotherapy. Stage 3/4 and vascular invasion were statically significant at disease-free survival analysis. Conclusion: The state of Maranhão has the highest incidence of penile cancer in Brazil and globally. Tumors are locally advanced and at the time of diagnosis, and there is a high frequency among young individuals. Patients have a low socioeconomic status, making it difficult to complete treatment and receive appropriate follow-up.