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10.1002/rth2.12092 http://scihub22266oqcxt.onion/10.1002/rth2.12092 C5974920!5974920 !30046725     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30046725 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Res+Pract+Thromb+Haemost 2018 ; 2 (2 ): 228-239 Nephropedia Template TP {{tp|p=30046725 |t=2018. Glycoprotein VI in securing vascular integrity in inflamed vessels |pdf=|usr=}}{{30046725 }} gab.com Text Glycoprotein VI in securing vascular integrity in inflamed vessels JO: Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046725 #FOAvip Glycoprotein VI (GPVI), the main platelet receptor for collagen, has been shown to play a central role in various models of thrombosis, and to be a minor actor of hemostasis at sites of trauma. These observations have made of GPVI a novel target for antithrombotic therapy, as its inhibition would ideally combine efficacy with safety. Nevertheless, recent studies have indicated that GPVI could play an important role in preventing bleeding caused by neutrophils in the inflamed skin and lungs. Remarkably, there is evidence that the GPVI-dependent hemostatic function of platelets at the acute phase of inflammation in these organs does not involve aggregation. From a therapeutic perspective, the vasculoprotective action of GPVI in inflammation suggests that blocking of GPVI might bear some risks of bleeding at sites of neutrophil infiltration. In this review, we summarize recent findings on GPVI functions in inflammation and discuss their possible clinical implications and applications. Twit Text FOAVip Glycoprotein VI in securing vascular integrity in inflamed vessels ????Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046725 #FOAvip English Wikipedia <ref>{{Cite pmid|30046725 }}</ref> Glycoprotein VI in securing vascular integrity in inflamed vessels #MMPMID30046725 Boulaftali Y ; Mawhin MA ; Jandrot-Perrus M ; Ho-Tin-Noé B Res Pract Thromb Haemost 2018[Apr]; 2 (2 ): 228-239 PMID30046725 show ga Glycoprotein VI (GPVI), the main platelet receptor for collagen, has been shown to play a central role in various models of thrombosis, and to be a minor actor of hemostasis at sites of trauma. These observations have made of GPVI a novel target for antithrombotic therapy, as its inhibition would ideally combine efficacy with safety. Nevertheless, recent studies have indicated that GPVI could play an important role in preventing bleeding caused by neutrophils in the inflamed skin and lungs. Remarkably, there is evidence that the GPVI-dependent hemostatic function of platelets at the acute phase of inflammation in these organs does not involve aggregation. From a therapeutic perspective, the vasculoprotective action of GPVI in inflammation suggests that blocking of GPVI might bear some risks of bleeding at sites of neutrophil infiltration. In this review, we summarize recent findings on GPVI functions in inflammation and discuss their possible clinical implications and applications. äGlycoprotein VI in securing vascular integrity in inflamed vessels (epmc).pdf DeepDyve Pubget Overpricing