Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-018-26724-7 http://scihub22266oqcxt.onion/10.1038/s41598-018-26724-7 C5974398!5974398!29844352     free     free     free       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29844352|t=2018. A physical model of cell metabolism |pdf=|usr=}}{{29844352}} gab.com Text A physical model of cell metabolism JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844352 #FOAvip Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate. The transition to aerobic fermentation and the maximum metabolic rate are currently understood based on enzymatic cost constraints. Yet, we are lacking a theory explaining the maintenance energy demand. Here we report a physical model of cell metabolism that explains the origin of these three energy scales. Our key hypothesis is that the maintenance energy demand is rooted on the energy expended by molecular motors to fluidize the cytoplasm and counteract molecular crowding. Using this model and independent parameter estimates we make predictions for the three energy scales that are in quantitative agreement with experimental values. The model also recapitulates the dependencies of cell growth with extracellular osmolarity and temperature. This theory brings together biophysics and cell biology in a tractable model that can be applied to understand key principles of cell metabolism. Twit Text FOAVip A physical model of cell metabolism ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844352 #FOAvip English Wikipedia <ref>{{Cite pmid|29844352}}</ref> A physical model of cell metabolism #MMPMID29844352 Fernandez-de-Cossio-Diaz J; Vazquez A Sci Rep 2018[]; 8 (ä): ä PMID29844352show ga Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate. The transition to aerobic fermentation and the maximum metabolic rate are currently understood based on enzymatic cost constraints. Yet, we are lacking a theory explaining the maintenance energy demand. Here we report a physical model of cell metabolism that explains the origin of these three energy scales. Our key hypothesis is that the maintenance energy demand is rooted on the energy expended by molecular motors to fluidize the cytoplasm and counteract molecular crowding. Using this model and independent parameter estimates we make predictions for the three energy scales that are in quantitative agreement with experimental values. The model also recapitulates the dependencies of cell growth with extracellular osmolarity and temperature. This theory brings together biophysics and cell biology in a tractable model that can be applied to understand key principles of cell metabolism. äA physical model of cell metabolism (epmc).pdf DeepDyve Pubget Overpricing