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10.1038/s41467-018-04446-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-04446-8 C5974375!5974375!29844422     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29844422&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29844422|t=2018. The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages |pdf=|usr=}}{{29844422}} gab.com Text The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29844422 #FOAvip Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in the Salmonella-containing vacuole (SCV). Hepcidin is reported to increase the mortality of Salmonella-infected animals by increasing the bacterial load in macrophages. Here we assess the iron levels and find that hepcidin increases iron content in the cytosol but decreases it in the SCV through FPN on the SCV membrane. Loss-of-FPN from the SCV via the action of hepcidin impairs the generation of bactericidal reactive oxygen species (ROS) as the iron content decreases. We conclude that FPN is required to provide sufficient iron to the SCV, where iron serves as a cofactor for the generation of antimicrobial ROS rather than as a nutrient for Salmonella. Twit Text FOAVip The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29844422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844422 #FOAvip English Wikipedia <ref>{{Cite pmid|29844422}}</ref> The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages #MMPMID29844422 Lim D; Kim KS; Jeong JH; Marques O; kim HJ; Song M; Lee TH; Kim JI; Choi HS; Min JJ; Bumann D; Muckenthaler MU; Choy HE Nat Commun 2018[]; 9 (ä): ä PMID29844422show ga Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in the Salmonella-containing vacuole (SCV). Hepcidin is reported to increase the mortality of Salmonella-infected animals by increasing the bacterial load in macrophages. Here we assess the iron levels and find that hepcidin increases iron content in the cytosol but decreases it in the SCV through FPN on the SCV membrane. Loss-of-FPN from the SCV via the action of hepcidin impairs the generation of bactericidal reactive oxygen species (ROS) as the iron content decreases. We conclude that FPN is required to provide sufficient iron to the SCV, where iron serves as a cofactor for the generation of antimicrobial ROS rather than as a nutrient for Salmonella. äThe hepcidin-ferroportin axis controls the iron content of Salmonella-(epmc).pdf DeepDyve Pubget Overpricing