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10.1038/s41598-018-26399-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-26399-0 C5974357!5974357 !29844460     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29844460 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 8196 Nephropedia Template TP {{tp|p=29844460 |t=2018. Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory |pdf=|usr=}}{{29844460 }} gab.com Text Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844460 #FOAvip Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One strategy, however, may produce disparate results for different biosynthetic pathways. We use a spatially resolved kinetic model to explore this fundamental design choice in systems and synthetic biology. We predict that two example biosynthetic pathways have distinct optimal organization strategies that vary based on pathway-dependent and cell-extrinsic factors. Moreover, we demonstrate that the optimal design varies as a function of kinetic and biophysical properties, as well as culture conditions. Our results suggest that organizing biosynthesis has the potential to substantially improve performance, but that choosing the appropriate strategy is key. The flexible design-space analysis we propose can be adapted to diverse biosynthetic pathways, and lays a foundation to rationally choose organization strategies for biosynthesis. Twit Text FOAVip Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844460 #FOAvip English Wikipedia <ref>{{Cite pmid|29844460 }}</ref> Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory #MMPMID29844460 Jakobson CM ; Tullman-Ercek D ; Mangan NM Sci Rep 2018[May]; 8 (1 ): 8196 PMID29844460 show ga Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One strategy, however, may produce disparate results for different biosynthetic pathways. We use a spatially resolved kinetic model to explore this fundamental design choice in systems and synthetic biology. We predict that two example biosynthetic pathways have distinct optimal organization strategies that vary based on pathway-dependent and cell-extrinsic factors. Moreover, we demonstrate that the optimal design varies as a function of kinetic and biophysical properties, as well as culture conditions. Our results suggest that organizing biosynthesis has the potential to substantially improve performance, but that choosing the appropriate strategy is key. The flexible design-space analysis we propose can be adapted to diverse biosynthetic pathways, and lays a foundation to rationally choose organization strategies for biosynthesis. |*Biosynthetic Pathways [MESH] |Algorithms [MESH] |Bacteria/enzymology/genetics/*metabolism [MESH] |Kinetics [MESH] |Metabolic Engineering/*methods [MESH] |Models, Biological [MESH] |Protein Engineering/methods [MESH] |Software [MESH]Spatially organizing biochemistry: choosing a strategy to translate sy(epmc).pdf DeepDyve Pubget Overpricing