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10.1038/s41419-018-0626-6 http://scihub22266oqcxt.onion/10.1038/s41419-018-0626-6 C5974346!5974346 !29844348     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29844348 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (6 ): 648 Nephropedia Template TP {{tp|p=29844348 |t=2018. HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect |pdf=|usr=}}{{29844348 }} gab.com Text HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29844348 #FOAvip Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1 expression in tumor tissue correlated with poor overall survival and higher HMGB1 concentration was detected in serum of patients who accepted radiotherapy. Collectively, the results from this study suggested that interaction between dead cells and surviving cells might influence the fate of tumor. HMGB1 could be a novel tumor promoter with therapeutic and prognostic relevance in cancers. Twit Text FOAVip HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29844348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844348 #FOAvip English Wikipedia <ref>{{Cite pmid|29844348 }}</ref> HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect #MMPMID29844348 He S ; Cheng J ; Sun L ; Wang Y ; Wang C ; Liu X ; Zhang Z ; Zhao M ; Luo Y ; Tian L ; Li C ; Huang Q Cell Death Dis 2018[May]; 9 (6 ): 648 PMID29844348 show ga Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1 expression in tumor tissue correlated with poor overall survival and higher HMGB1 concentration was detected in serum of patients who accepted radiotherapy. Collectively, the results from this study suggested that interaction between dead cells and surviving cells might influence the fate of tumor. HMGB1 could be a novel tumor promoter with therapeutic and prognostic relevance in cancers. |Antigens, Neoplasm/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/radiation effects [MESH] |Cell Survival/radiation effects [MESH] |Female [MESH] |HMGB1 Protein/*metabolism [MESH] |Humans [MESH] |MAP Kinase Signaling System/radiation effects [MESH] |Male [MESH] |Middle Aged [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |Multivariate Analysis [MESH] |Neoplasms/*metabolism/*pathology [MESH] |Paracrine Communication/*radiation effects [MESH] |Prognosis [MESH] |Protein Binding [MESH]HMGB1 released by irradiated tumor cells promotes living tumor cell pr(epmc).pdf DeepDyve Pubget Overpricing