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10.1038/s41467-018-04524-x http://scihub22266oqcxt.onion/10.1038/s41467-018-04524-x C5974295!5974295!29844317     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29844317|t=2018. Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node |pdf=|usr=}}{{29844317}} gab.com Text Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29844317 #FOAvip CD4+ T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human cancers are not secreted. The fate of Ag-specific CD4+ T cells recognizing a cytoplasmic Ag in mice bearing autochthonous tumors is still unclear. Here we show, using a genetically engineered lung adenocarcinoma mouse model, that naive tumor-specific CD4+ T cells are activated and proliferate in the tumor-draining lymph node (TdLN) but do not differentiate into effectors or accumulate in tumors. Instead, these CD4+ T cells are driven toward anergy or peripherally-induced Treg (pTreg) differentiation, from the early stage of tumor development. This bias toward immune suppression is restricted to the TdLN, and is maintained by Tregs enriched in the tumor Ag-specific cell population. Thus, tumors may enforce a dominant inhibition of the anti-tumor CD4 response in the TdLN by recapitulating peripheral self-tolerance mechanisms. Twit Text FOAVip Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29844317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844317 #FOAvip English Wikipedia <ref>{{Cite pmid|29844317}}</ref> Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node #MMPMID29844317 Alonso R; Flament H; Lemoine S; Sedlik C; Bottasso E; Péguillet I; Prémel V; Denizeau J; Salou M; Darbois A; Núñez NG; Salomon B; Gross D; Piaggio E; Lantz O Nat Commun 2018[]; 9 (ä): ä PMID29844317show ga CD4+ T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human cancers are not secreted. The fate of Ag-specific CD4+ T cells recognizing a cytoplasmic Ag in mice bearing autochthonous tumors is still unclear. Here we show, using a genetically engineered lung adenocarcinoma mouse model, that naive tumor-specific CD4+ T cells are activated and proliferate in the tumor-draining lymph node (TdLN) but do not differentiate into effectors or accumulate in tumors. Instead, these CD4+ T cells are driven toward anergy or peripherally-induced Treg (pTreg) differentiation, from the early stage of tumor development. This bias toward immune suppression is restricted to the TdLN, and is maintained by Tregs enriched in the tumor Ag-specific cell population. Thus, tumors may enforce a dominant inhibition of the anti-tumor CD4 response in the TdLN by recapitulating peripheral self-tolerance mechanisms. äInduction of anergic or regulatory tumor-specific CD4+ T cells in the (epmc).pdf DeepDyve Pubget Overpricing